Synthesis and biological evaluation of PEG-tirofiban conjugates

被引：3
|
作者：
Desaubry, Laurent [1 ]
Riche, Stephanie [1 ]
Laeuffer, Patricia [2 ]
Cazenave, Jean-Pierre [2 ]
机构：
[1] Univ Strasbourg 1, Fac Pharm, CNRS, LCI,UMR 7175, F-67401 Illkirch Graffenstaden, France
[2] INSERM, U311, EFS Alsace, F-67065 Strasbourg, France
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 06期
关键词：
D O I：
10.1016/j.bmcl.2008.01.118
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
We have conjugated tiro. ban, an antagonist of the GPIIb/IIIa integrin receptor, to PEG, and shown that these polymers effectively inhibit platelet aggregation. This inhibition decreased with the size of the polymer. Our goal was to develop new cryoprotective agents to store frozen platelets. Surprisingly, tirofoban-conjugated PEG did not exhibit any protection. (c) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2028 / 2031
页数：4
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