Pharmacological Activities of Extracts and Compounds Isolated from Mediterranean Sponge Sources

被引：6

作者：

Di Cesare Mannelli, Lorenzo ^{[1
]}

Palma Esposito, Fortunato ^{[2
]}

Sangiovanni, Enrico ^{[3
]}

Pagano, Ester ^{[4
]}

Mannucci, Carmen ^{[5
]}

Polini, Beatrice ^{[6
]}

Ghelardini, Carla ^{[1
]}

Dell'Agli, Mario ^{[3
]}

Izzo, Angelo Antonio ^{[4
]}

Calapai, Gioacchino ^{[5
]}

de Pascale, Donatella ^{[2
]}

Nieri, Paola ^{[6
,7
]}

机构：

[1] Univ Florence, Sect Pharmacol & Toxicol, Dept Neurosci Psychol Drug Res & Child Hlth, I-50139 Florence, Italy

[2] Stn Zool Anton Dohrn, Dept Marine Biotechnol, I-80121 Naples, Italy

[3] Univ Milan, Dept Pharmacol & Biomol Sci, I-20133 Milan, Italy

[4] Univ Naples Federico II, Sch Med & Surg, Dept Pharm, I-80131 Naples, Italy

[5] Univ Messina, Dept Biomed & Dent Sci & Morphol & Funct Imaging, I-98125 Messina, Italy

[6] Univ Pisa, Dept Pharm, I-56126 Pisa, Italy

[7] Univ Pisa, Interdept Ctr Marine Pharmacol MarinePHARMA, I-56126 Pisa, Italy

来源：

PHARMACEUTICALS | 2021年 / 14卷 / 12期

关键词：

Mediterranean sponges; marine natural products; antimicrobials; antiproliferative; anti-inflammatory; marine pharmacology; blue biotechnology; Mediterranean Sea; BIOACTIVE BROMOPYRROLE ALKALOIDS; MARINE SPONGES; CHEMICAL DIVERSITY; IN-VITRO; PANICEINS; INHIBIT; AVAROL; SESQUITERPENOIDS; METABOLITES; PSAMMAPLIN;

D O I：

10.3390/ph14121329

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Marine pharmacology is an exciting and growing discipline that blends blue biotechnology and natural compound pharmacology together. Several sea-derived compounds that are approved on the pharmaceutical market were discovered in sponges, marine organisms that are particularly rich in bioactive metabolites. This paper was specifically aimed at reviewing the pharmacological activities of extracts or purified compounds from marine sponges that were collected in the Mediterranean Sea, one of the most biodiverse marine habitats, filling the gap in the literature about the research of natural products from this geographical area. Findings regarding different Mediterranean sponge species were individuated, reporting consistent evidence of efficacy mainly against cancer, infections, inflammatory, and neurological disorders. The sustainable exploitation of Mediterranean sponges as pharmaceutical sources is strongly encouraged to discover new compounds.

引用

页数：25

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