Molecular biology of oral cavity squamous cell carcinoma

被引：24

作者：

Hsu, Phillip J. ^{[1
]}

Yan, Kenneth ^{[2
]}

Shi, Hailing ^{[3
,4
]}

Izumchenko, Evgeny ^{[5
]}

Agrawal, Nishant ^{[2
]}

机构：

[1] Univ Chicago, Med Scientist Training Program, Chicago, IL 60637 USA

[2] Univ Chicago Med, Dept Surg, Sect Otolaryngol Head & Neck Surg, Chicago, IL 60637 USA

[3] Univ Chicago, Howard Hughes Med Inst, Dept Chem, Chicago, IL 60637 USA

[4] Univ Chicago, Howard Hughes Med Inst, Inst Biophys Dynam, Chicago, IL 60637 USA

[5] Univ Chicago Med, Dept Med, Sect Hematol Oncol, Chicago, IL 60637 USA

来源：

ORAL ONCOLOGY | 2020年 / 102卷

关键词：

Oral cancer; Oral cavity cancer; Head and neck cancer; Squamous cell carcinoma; Head and neck squamous cell carcinoma; HNSCC; Cancer genetics; Molecular biology of oral cavity squamous cell carcinoma; Immunotherapy; Epigenetics; GROWTH-FACTOR RECEPTOR; EPITHELIAL-MESENCHYMAL TRANSITION; EGFR SIGNALING NETWORK; CYCLIN D1 EXPRESSION; GENE COPY NUMBER; PROMOTER METHYLATION; DNA METHYLATION; E-CADHERIN; IMMUNOHISTOCHEMICAL EXPRESSION; SURGICAL MARGINS;

D O I：

10.1016/j.oraloncology.2019.104552

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Oral cavity squamous cell carcinoma (OCSCC) is a heterogeneous and complex disease that arises due to dysfunction of multiple molecular signaling pathways. Recent advances in high-throughput genetic sequencing technologies coupled with innovative analytical techniques have begun to characterize the molecular determinants driving OCSCC. An understanding of the key molecular signaling networks underlying the initiation and progression of is essential for informing treatment of the disease. In this chapter, we discuss recent findings of key genes altered in OCSCC and potential treatments targeting these genes.

引用

页数：7

共 50 条

[1] Molecular biology of oral cavity squamous cell carcinoma
Kupferman, ME
Myers, JN
OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA, 2006, 39 (02) : 229 - +
[2] SQUAMOUS CELL CARCINOMA OF ORAL CAVITY
ROSENFELD, L
CALLAWAY, J
SOUTHERN MEDICAL JOURNAL, 1963, 56 (12) : 1394 - &
[3] Squamous cell carcinoma of the oral cavity
Stanko, P.
Satko, I.
Czako, L.
Beno, M.
Danko, J.
Zmeko, S.
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, 2007, 108 (07): : 292 - 296
[4] A look at the biology of spindle cell squamous carcinoma of the oral cavity: Report of a case
Rizzardi, C
Frezzini, C
Maglione, M
Tirelli, G
Melato, M
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2003, 61 (02) : 264 - 268
[5] Molecular Parameter for Recurrence Calculation in Squamous Cell Carcinoma of Oral Cavity
Matthias, K.
Pabst, U.
Kotrba, J.
Kaune, T.
Wichmann, H.
Guettler, A.
Bache, M.
Vordermark, D.
Eckert, A. W.
ONCOLOGY RESEARCH AND TREATMENT, 2016, 39 : 105 - 105
[6] Molecular analysis of anoikis resistance in oral cavity squamous cell carcinoma
Kupferman, Michael E.
Patel, Vyomesh
Sriuranpong, Virote
Amornphimoltham, Panamwat
Jasser, Samar A.
Mandal, Mahitosh
Zhou, Ge
Wang, Jing
Coombes, Kevin
Multani, Asha
Pathak, Sen
Gutkind, J. Silvio
Myers, Jeffrey N.
ORAL ONCOLOGY, 2007, 43 (05) : 440 - 454
[7] Clinical, pathological and molecular determinants in squamous cell carcinoma of the oral cavity
Al-Swiahb, Jamil N.
Chen, Chang-Han
Chuang, Hui-Ching
Fang, Fu-Min
Tasi, Hsin-Ting
Chien, Chih-Yen
FUTURE ONCOLOGY, 2010, 6 (05) : 837 - 850
[8] Oral leukoplakia and oral cavity squamous cell carcinoma
Bewley, Arnaud F.
Farwell, D. Gregory
CLINICS IN DERMATOLOGY, 2017, 35 (05) : 461 - 467
[9] Chemoprevention of squamous cell carcinoma of the oral cavity
Brown, KS
Kane, MA
OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA, 2006, 39 (02) : 349 - +
[10] Lip and Oral Cavity Squamous Cell Carcinoma
Howard, Adam
Agrawal, Nishant
Gooi, Zhen
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA, 2021, 35 (05) : 895 - 911

← 1 2 3 4 5 →