The Ras-related Rho GTPases, Rac1 and Rac2 regulate the homing, engraftment and mobilization of hematopoietic stem cells and progenitor cells.

被引：0
|
作者：
Cancelas, JA
Gu, Y
Filippi, MD
Prabhakar, R
Lee, AW
Siefiring, JE
Williams, DA
机构：
[1] Cincinnati Childrens Res Fdn, Div Expt Hematol, Cincinnati, OH USA
[2] Hoxworth Blood Ctr, Res Dept, Cincinnati, OH USA
来源：
BLOOD | 2003年 / 102卷 / 11期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
742
引用
下载
收藏
页码：212A / 212A
页数：1
相关论文
共 50 条
  • [1] Deficiency of the Ras-related Rho GTPases, Rac1 and Rac2, impairs the normal organ distribution of myeloid cells and progenitor engraftment in vivo.
    Cancelas, JA
    Prabhakar, R
    Lee, AW
    Siefring, JE
    Bailey, JR
    Witte, DP
    Kwiatkowski, DJ
    Williams, DA
    BLOOD, 2002, 100 (11) : 60A - 60A
  • [2] Rac1 and Rac2 Rho GTPases distinctly regulate stem cell engraftment and mobilization and are novel targets for pharmacologically-induced progenitor mobilization.
    Cancelas, JA
    Lee, AW
    Prabhakar, R
    Jansen, M
    Zheng, Y
    Williams, DA
    BLOOD, 2004, 104 (11) : 36A - 36A
  • [3] The highly related Rho GTPases, Rac1 and Rac2, separately control hematopoietic cell survival and cycle progression, but together regulate the engraftment phenotype.
    Yi, G
    Filippi, MD
    Cancelas, JA
    Siefring, JE
    Williams, EP
    Jasti, A
    Prabhakar, R
    Kwiatkowski, DJ
    Williams, DA
    BLOOD, 2002, 100 (11) : 191A - 191A
  • [4] The Rho GTPases Rac1 and Rac2 are critical regulators of hematopoietic stem cell adhesion, survival and proliferation
    Gu, Y
    Siefring, JE
    Williams, EP
    Cancelas, J
    Jasti, AC
    Atkinson, SJ
    Kwiatkowski, DJ
    Williams, DA
    EXPERIMENTAL HEMATOLOGY, 2003, 31 (07) : 64 - 64
  • [5] Stimulation of phospholipase C-β2 by the Rho GTPases RAC1 and RAC2
    Stephan, I
    Schwald, F
    Gierschik, P
    Illenberger, D
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1998, 357 (04) : R62 - R62
  • [6] Differential Localization of RAC1 and RAC2 Reflects Their Specific Functions in Normal and Leukemic Human Hematopoietic Stem/Progenitor Cells
    Capala, Marta Ewa
    Maat, Henny
    Bonardi, Francesco
    Vellenga, Edo
    Schuringa, Jan Jacob
    BLOOD, 2012, 120 (21)
  • [7] DIFFERENTIAL LOCALIZATION OF RAC1 AND RAC2 REFLECTS THEIR SPECIFIC FUNCTIONS IN NORMAL AND LEUKEMIC HUMAN HEMATOPOIETIC STEM/PROGENITOR CELLS
    Capala, Marta
    Maat, Henny
    Bonardi, Francesco
    Vellenga, Edo
    Schuringa, Jan
    EXPERIMENTAL HEMATOLOGY, 2012, 40 (08) : S50 - S50
  • [8] Differential Localization Of RAC1 and RAC2 Reflects Their Specific Functions In Normal and Leukemic Human Hematopoietic Stem/Progenitor Cells
    Capala, Marta Ewa
    Bonardi, Francesco
    Maat, Henny
    Vellenga, Edo
    Schuringa, Jan Jacob
    BLOOD, 2013, 122 (21)
  • [9] The highly related Rho GTPases Rac1 and Rac2 together regulate the engrafting phenotype but separately control hematopoietic stem cell survival, cycle progression and multiple cell functions
    Williams, D
    Gu, Y
    Filippi, M
    Prabhakar, R
    Atkinson, S
    Cancelas, J
    EXPERIMENTAL HEMATOLOGY, 2003, 31 (07) : 187 - 188
  • [10] The small GTPases Rac 1 and 2 regulate migration, adhesion and homing of haematopoietic progenitor cells to tumours
    Lang, V.
    Goettig, S.
    Gille, J.
    Cancelas, J.
    Williams, D.
    Seifried, E.
    Henschler, R.
    BONE MARROW TRANSPLANTATION, 2010, 45 : S52 - S52
12345