Monitoring therapeutic effects in Parkinson's disease by serial imaging of the nigrostriatal dopaminergic pathway

被引：9
|
作者：
Booij, Jan [1 ]
Berendse, Henk W. [2 ]
机构：
[1] Univ Amsterdam, Acad Med Ctr, Dept Nucl Med, NL-1105 AZ Amsterdam, Netherlands
[2] Vrije Univ Amsterdam Med Ctr, Dept Neurol, Amsterdam, Netherlands
来源：
JOURNAL OF THE NEUROLOGICAL SCIENCES | 2011年 / 310卷 / 1-2期
关键词：
Parkinson's disease; Dopamine; PET; SPECT; Progression; NEUROTROPHIC FACTOR; CONTROLLED-TRIAL; DOUBLE-BLIND; HUMAN BRAIN; PHASE-I; PROGRESSION; TRANSPORTER; SPECT; PET; LEVODOPA;
D O I：
10.1016/j.jns.2011.07.029
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
PET and SPECT are very sensitive techniques to detect in-vivo nigrostriatal degeneration in Parkinson's disease, even in the pre-motor phase of the disease. Furthermore, these techniques are able to measure disease progression. However, caution must be used in the interpretation of studies in which therapeutic effects in Parkinson's disease were also monitored by serial imaging of nigrostriatal neurons, as disparity between imaging and clinical outcomes has been reported in several clinical studies. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：40 / 43
页数：4
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