SERS-Based Ultrasensitive Lateral Flow Assay for Quantitative Sensing of Protein Biomarkers

被引：8

作者：

Gunawardhana, Loku ^{[1
]}

Kourentzi, Katerina ^{[2
]}

Danthanarayana, Adheesha N. ^{[3
]}

Brgoch, Jakoah ^{[3
]}

Shan, Xiaonan ^{[1
]}

Willson, Richard C. ^{[3
]}

Wei-Chuan Shih ^{[1
]}

机构：

[1] Univ Houston, Dept Elect & Comp Engn, Houston, TX 77204 USA

[2] Univ Houston, Dept Chem & Biomol Engn, Houston, TX 77204 USA

[3] Univ Houston, Dept Chem, Univ Pk, Houston, TX 77204 USA

来源：

IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS | 2021年 / 27卷 / 05期

关键词：

Nanoparticles; Gold; Biomarkers; Raman scattering; Strips; Sensitivity; Multiplexing; Laser biomedical applications; lateral flow assay (LFA); nanotechnology; plasmons; surface enhanced raman scattering (SERS); SURFACE-ENHANCED RAMAN; SENSITIVE DETECTION; TROPONIN-T; LABEL; HCG; SPECTROSCOPY; IMMUNOASSAY; MICROSCOPY; POINT;

D O I：

10.1109/JSTQE.2021.3062548

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

The remarkable optical properties of surface-enhanced Raman scattering (SERS) has prompted the design and fabrication of SERS nanoparticles as biosensing and imaging labels. Among a variety of biosensing assay platforms within the growing point of care technology (POCT) field, lateral flow assay (LFA) has gained significant attention because of their simplicity, low cost, and user-friendly assay protocols. Herein, we show the development and performance benchmarking of SERS-based LFA for rapid and quantitative sensing of two important biomarkers: hCG and cTnT. The results suggest the feasibility of this platform for POCT applications.

引用

页数：8

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