Neuroendocrine Peptides of the Gut and Their Role in the Regulation of Food Intake

被引：15
|
作者：
Schalla, Martha A. [1 ,2 ,3 ]
Tache, Yvette [4 ,5 ]
Stengel, Andreas [1 ,2 ,3 ,6 ]
机构：
[1] Charite Univ Med Berlin, Dept Psychosomat Med, Charite Ctr Internal Med & Dermatol, Berlin, Germany
[2] Free Univ Berlin, Berlin, Germany
[3] Humboldt Univ, Berlin Inst Hlth, Berlin, Germany
[4] UCLA, David Geffen Sch Med, Digest Dis Res Ctr,Dept Med,CURE, Dept Med,Vatche & Tamar Manoukian Div Digest Dis, Los Angeles, CA 90095 USA
[5] VA Greater Angeles Healthcare Syst, Los Angeles, CA USA
[6] Med Univ Hosp Tubingen, Dept Psychosomat Med & Psychotherapy, Tubingen, Germany
来源：
COMPREHENSIVE PHYSIOLOGY | 2021年 / 11卷 / 02期
关键词：
GLUCAGON-LIKE PEPTIDE-1; GROWTH-HORMONE SECRETAGOGUE; GHRELIN-O-ACYLTRANSFERASE; GASTRIC BYPASS-SURGERY; DEPENDENT INSULINOTROPIC POLYPEPTIDE; RECEPTOR MESSENGER-RNA; BIOACTIVE ENTEROGLUCAGON OXYNTOMODULIN; VENTRAL TEGMENTAL AREA; CENTRAL-NERVOUS-SYSTEM; NESFATIN-1 STIMULATES GLUCAGON;
D O I：
10.1002/cphy.c200007
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The regulation of food intake encompasses complex interplays between the gut and the brain. Among them, the gastrointestinal tract releases different peptides that communicate the metabolic state to specific nuclei in the hindbrain and the hypothalamus. The present overview gives emphasis on seven peptides that are produced by and secreted from specialized enteroendocrine cells along the gastrointestinal tract in relation with the nutritional status. These established modulators of feeding are ghrelin and nesfatin-1 secreted from gastric X/A-like cells, cholecystokinin (CCK) secreted from duodenal I-cells, glucagon-like peptide 1 (GLP-1), oxyntomodulin, and peptide YY (PYY) secreted from intestinal L-cells and uroguanylin (UGN) released from enterochromaffin (EC) cells. ?? 2021 American Physiological Society. Compr Physiol 11:1679-1730, 2021.
引用
收藏
页码：1679 / 1730
页数：52
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