LINC00961 inhibits the migration and invasion of colon cancer cells by sponging miR-223-3p and targeting SOX11

被引：23
|
作者：
Wu, Haixia [1 ]
Dai, Yuedi [1 ]
Zhang, Dexiang [2 ]
Zhang, Xiaoyu [3 ]
He, Zhiyun [4 ]
Xie, Xiaojun [5 ]
Cai, Chudong [6 ]
机构：
[1] Fudan Univ, Dept Med Oncol, Minhang Branch, Canc Hosp, Shanghai, Peoples R China
[2] Fudan Univ, Zhongshan Xuhui Hosp, Gen Surg Dept, Shanghai, Peoples R China
[3] Xuzhou Med Univ, Dept Gen Surg, Div Gastrointestinal Surg, Huaian Second Peoples Hosp,Affiliated Huaian Hosp, Huaian, Peoples R China
[4] Lanzhou Univ, Tolorectal Surg Dept, Hosp 2, Lanzhou, Peoples R China
[5] Shantou Univ, Affiliated Hosp 1, Dept Gen Surg, Med Coll, Shantou, Peoples R China
[6] Sun Yat Sen Univ, Dept Gen Surg, Shantou Cent Hosp, Affiliated Shantou Hosp, Shantou, Peoples R China
来源：
CANCER MEDICINE | 2020年 / 9卷 / 07期
关键词：
colon cancer; invasion; LINC00961; migration; miR-223-3p; SOX11; COLORECTAL-CANCER; MESENCHYMAL TRANSITION; PROLIFERATION; PROMOTES; RNA; METASTASIS; PROGRESSION; EXPRESSION; APOPTOSIS; GROWTH;
D O I：
10.1002/cam4.2850
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Long noncoding RNAs play essential roles in colon cancer tumorigenesis. This study aimed to explore the potential function and molecular mechanisms of LINC00961 in colon cancer. qPCR results showed that LINC00961 was downregulated in colon cancer cells and tissues. Functional assays demonstrated that LINC00961 suppressed the migration and invasion of colon cancer cells in vitro. LINC00961 functioned as an endogenous sponge for miR-223-3p in colon cancer cells. SOX11 was confirmed as a target gene of miR-223-3p. The effect of miR-223-3p on colon cancer cells was then investigated. MiR-223-3p inhibition enhanced their migration and invasion. The effect of SOX11 on colon cancer cells was studied. SOX11 overexpression inhibited the invasion of colon cancer cells. LINC00961 acted as an anti-oncogene and upregulated SOX11 expression by functioning as a miR-223-3p sponge. This research revealed the molecular mechanism of LINC00961 in colon cancer. LINC00961 might act as a potential diagnostic biomarker and therapeutic target for further clinical treatments.
引用
收藏
页码：2514 / 2523
页数：10
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