A novel indole-diterpenoid, JBIR-03 with anti-MRSA activity from Dichotomomyces cejpii var. cejpii NBRC 103559

被引：45

作者：

Ogata, Masahiro

Ueda, Jun-ya

Hoshi, Midori

Hashimoto, Junko

Nakashima, Takuji

Anzai, Kozue

Takagi, Motoki

Shin-ya, Kazuo

机构：

[1] Natl Inst Adv Ind Sci & Technol, BIRC, Koto Ku, Tokyo 1350064, Japan

[2] JBIC, JBIRC, Koto Ku, Tokyo 1350064, Japan

[3] Aomori Univ, Fac Pharmaceut Sci, Dept Microbiol, Aomori 0300943, Japan

[4] NITE, NITE Biol Resource Ctr NBRC, Chiba 2920818, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2007年 / 60卷 / 10期

关键词：

JBIR-03; indole-diterpene; Dichotomomyces cejpii; MRSA; Valsa ceratosperma;

D O I：

10.1038/ja.2007.83

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new indole-diterpene, JBIR-03 (1), was isolated from the fungus Dichotomomyces cejpii var. cejpii NBRC 103559 and its structure was determined based on the spectroscopic data. 1 exhibited anti-MRSA (methicillin-resistant Staphylococcus aureus) activity and antifungal activity against apple Valsa canker-causing fungus, Valsa ceratosperma, while it exhibited no toxicity towards human cancer cells.

引用

页码：645 / 648

页数：4