Readily tunable and bifunctional L-prolinamide derivatives: Design and application in the direct enantioselective aldol reactions

被引：200
|
作者：
Chen, JR [1 ]
Lu, HH [1 ]
Li, XY [1 ]
Cheng, L [1 ]
Wan, J [1 ]
Xiao, WJ [1 ]
机构：
[1] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China
来源：
ORGANIC LETTERS | 2005年 / 7卷 / 20期
关键词：
D O I：
10.1021/ol0520323
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
graph Readily tunable and bifunctional L-prolinamides as novel organocatalysts have been developed, and their catalytic activities were evaluated in the direct asymmetric Aldol reactions of various aromatic aldehydes and cyclohexanone. High isolated yields (up to 94%), enantioselectivities (up to 99% ee), and anti-diastereoselectivities (up to 99:1) were obtained under the optimal conditions.
引用
收藏
页码：4543 / 4545
页数：3
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