Nucleolar proteins with altered expression in leukemic cell lines

被引：14

作者：

Teittinen, Kaisa J. ^{[1
,2
]}

Karkkainen, Pauliina ^{[1
,2
]}

Salonen, Johanna ^{[3
]}

Ronnholm, Gunilla ^{[4
]}

Korkeamaki, Hanna ^{[1
,2
]}

Vihinen, Mauno ^{[3
]}

Kalkkinen, Nisse ^{[4
]}

Lohi, Olli ^{[1
,2
]}

机构：

[1] Univ Tampere, Sch Med, Paediat Res Ctr, FIN-33520 Tampere, Finland

[2] Tampere Univ Hosp, Tampere, Finland

[3] Univ Tampere, Inst Biomed Technol, FIN-33520 Tampere, Finland

[4] Univ Helsinki, Inst Biotechnol, Helsinki, Finland

来源：

LEUKEMIA RESEARCH | 2012年 / 36卷 / 02期

基金：

芬兰科学院;

关键词：

Leukemia; Nucleolus; Proteomics; Mass spectrometry; Cell line; Differential protein expression; FRONTOTEMPORAL LOBAR DEGENERATION; TDP-43; PROHIBITIN; NUCLEUS; NUCLEOPHOSMIN; RB;

D O I：

10.1016/j.leukres.2011.06.038

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The function of the nucleolus is intimately connected to cell proliferation, division and growth. Many cancer cells have enlarged nucleoli, and several nucleolar proteins have been linked to tumorigenesis. In order to find proteins whose expression is altered in the nucleoli of leukemic cells, we carried out two-dimensional difference gel electrophoresis (2-D DIGE) analyses. Prohibitin (PHB) and TAR-DNA-binding protein-43 (TDP-43) were strongly expressed in the nucleoli of the pre-B-ALL cell line MHH-CALL3. Our results demonstrate that leukemic cells have differences in their nucleolar protein composition, and suggest that it may be possible to exploit these differences in identification of leukemia subtypes. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：232 / 236

页数：5

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