Ganglioside/protein kinase signals triggering cytoskeletal actin reorganization

被引：24
|
作者：
Higashi, H
Chen, NH
机构：
[1] Mitsubishi Kagaku Inst Life Sci, Tokyo 1948511, Japan
[2] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
[3] Peking Union Med Coll, Beijing 100050, Peoples R China
来源：
GLYCOCONJUGATE JOURNAL | 2003年 / 20卷 / 01期
关键词：
ganglioside; CaMKII; A-kinase; N-acetylgalactosamine; dendritogenesis;
D O I：
10.1023/B:GLYC.0000016742.88750.1a
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Exposure of neuronal cells to nanomolar concentrations of oligosaccharide portions of ganglioside GM2 and GT1b stimulates cAMP-dependent protein kinase (PKA) and Ca2+/calmodulin-dependent protein kinase II ( CaMKII), respectively, in a few seconds suggesting the presence of glyco-receptor-like molecules on the surface of the cells. Both GM2/PKA (GalNAc/PKA) and GT1b/CaMKII signaling cascades induced cytoskeletal actin reorganization through Cdc42 activation leading to filopodia formation within 2 min. Long-term effects of these glyco-signals were facilitation of dendritic differentiation of primary cultured hippocampal neurons and cerebellar Purkinje neurons indicating physiological roles of the signals in neuronal differentiation and maturation.
引用
收藏
页码：49 / 58
页数：10
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