Genetic and epigenetic studies in non-syndromic oral clefts

被引：22

作者：

Alade, Azeez ^{[1
,2
,3
]}

Awotoye, Waheed ^{[1
,2
]}

Butali, Azeez ^{[1
,2
]}

机构：

[1] Univ Iowa, Coll Dent, Dept Oral Pathol Radiol & Med, Iowa City, IA 52242 USA

[2] Univ Iowa, Iowa Inst Oral Hlth Res, Iowa City, IA USA

[3] Univ Iowa, Coll Publ Hlth, Dept Epidemiol, Iowa City, IA USA

来源：

ORAL DISEASES | 2022年 / 28卷 / 05期

关键词：

epigenetics; genetics; Non-syndromic clefts; GENOME-WIDE ASSOCIATION; METHYLENETETRAHYDROFOLATE REDUCTASE GENE; GROWTH-FACTOR-ALPHA; OROFACIAL CLEFTS; CANDIDATE GENES; LINKAGE ANALYSIS; COMMON MUTATION; RARE VARIANTS; MSX1; MUTATION; RISK-FACTOR;

D O I：

10.1111/odi.14146

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

The etiology of non-syndromic oral clefts (NSOFC) is complex with genetics, genomics, epigenetics, and stochastics factors playing a role. Several approaches have been applied to understand the etiology of non-syndromic oral clefts. These include linkage, candidate gene association studies, genome-wide association studies, whole-genome sequencing, copy number variations, and epigenetics. In this review, we shared these approaches, genes, and loci reported in some studies.

引用

页码：1339 / 1350

页数：12

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