Characteristics of HLA-E Restricted T-Cell Responses and Their Role in Infectious Diseases

被引：64
|
作者：
Joosten, Simone A. [1 ]
Sullivan, Lucy C. [2 ]
Ottenhoff, Tom H. M. [1 ]
机构：
[1] Leiden Univ, Dept Infect Dis, Med Ctr, NL-2333 ZA Leiden, Netherlands
[2] Univ Melbourne, Dept Microbiol & Immunol, Peter Doherty Inst Infect & Immun, Melbourne, Vic 3010, Australia
来源：
JOURNAL OF IMMUNOLOGY RESEARCH | 2016年 / 2016卷
关键词：
PEPTIDE-BINDING-SPECIFICITY; HUMAN CYTOMEGALOVIRUS; E EXPRESSION; E GENE; ANTIGEN; RECOGNITION; IDENTIFICATION; LYMPHOCYTES; SUBSET; TUBERCULOSIS;
D O I：
10.1155/2016/2695396
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Human HLA-E can, in addition to self-antigens, also present pathogen-derived sequences, which elicit specific T-cell responses. T-cells recognize their antigen presented by HLA-E highly specifically and have unique functional and phenotypical properties. Pathogen specific HLA-E restricted CD8(+) T-cells are an interesting new player in the field of immunology. Future work should address their exact roles and relative contributions in the immune response against infectious diseases.
引用
收藏
页数：11
相关论文
共 50 条
  • [1] Structure and function of T-cell receptors and their role in infectious diseases
    Zaragoza, OP
    Magana, TS
    Rodriguez, RB
    Marina, VM
    [J]. REVISTA DE INVESTIGACION CLINICA-CLINICAL AND TRANSLATIONAL INVESTIGATION, 1996, 48 (01): : 69 - 79
  • [2] Age-Associated Heterogeneity of Ty21a-Induced T Cell Responses to HLA-E Restricted Salmonella Typhi Antigen Presentation
    Rudolph, Mark E.
    McArthur, Monica A.
    Magder, Laurence S.
    Barnes, Robin S.
    Chen, Wilbur H.
    Sztein, Marcelo B.
    [J]. FRONTIERS IN IMMUNOLOGY, 2019, 10
  • [3] HLA-E restricted CD8+ T cell subsets are phenotypically altered in multiple sclerosis patients
    Pannemans, Kim
    Broux, Bieke
    Goris, An
    Dubois, Benedicte
    Broekmans, Tom
    Van Wijmeersch, Bart
    Geraghty, Daniel
    Stinissen, Piet
    Hellings, Niels
    [J]. MULTIPLE SCLEROSIS JOURNAL, 2014, 20 (07) : 790 - 801
  • [4] NK-CTLs, a novel HLA-E-restricted T-cell subset
    Moretta, L
    Romagnani, C
    Pietra, G
    Moretta, A
    Mingari, MC
    [J]. TRENDS IN IMMUNOLOGY, 2003, 24 (03) : 136 - 143
  • [5] T-Cell Therapy: Options for Infectious Diseases
    Parida, Shreemanta K.
    Poiret, Thomas
    Zhenjiang, Liu
    Meng, Qingda
    Heyckendorf, Jan
    Lange, Christoph
    Ambati, Aditya S.
    Rao, Martin V.
    Valentini, Davide
    Ferrara, Giovanni
    Rangelova, Elena
    Dodoo, Ernest
    Zumla, Alimuddin
    Maeurer, Markus
    [J]. CLINICAL INFECTIOUS DISEASES, 2015, 61 : S217 - S224
  • [6] NK CELL ACTIVATION IS DEPENDENT ON HLA-E SURFACE EXPRESSION AND THE PEPTIDE PRESENTED BY HLA-E
    Lauterbach, Nina
    Wieten, Lotte
    van Zon, Laura
    Voorter, Christina E. M.
    Tilanus, Marcel G. J.
    [J]. HUMAN IMMUNOLOGY, 2011, 72 : S179 - S179
  • [7] Human Amnion Epithelial Cells Impair T Cell Proliferation: The Role of HLA-G and HLA-E Molecules
    Morandi, Fabio
    Marimpietri, Danilo
    Goergens, Andre
    Gallo, Alessia
    Srinivasan, Raghuraman Chittor
    El-Andaloussi, Samir
    Gramignoli, Roberto
    [J]. CELLS, 2020, 9 (09) : 1 - 15
  • [8] THE ROLE OF HLA IN T-CELL ACTIVATION
    THORSBY, E
    [J]. HUMAN IMMUNOLOGY, 1984, 9 (01) : 1 - 7
  • [9] Human T cell receptor-mediated recognition of HLA-E
    García, P
    Llano, M
    de Heredia, AB
    Willberg, CB
    Caparrós, E
    Aparicio, P
    Braud, VM
    López-Botet, M
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 2002, 32 (04) : 936 - 944
  • [10] Are HLA-E Restricted CD8+ T Cells Functionally Altered in Multiple Sclerosis?
    Pannemans, Kim
    Goris, An
    Dobosi, Rita
    Dubois, Benedicte
    van Wijmeersch, Bart
    Stinissen, P.
    Hellings, Niels
    [J]. CLINICAL IMMUNOLOGY, 2009, 131 : S125 - S125
12345