Sulcal morphology as cognitive decline predictor in older adults with memory complaints

被引：2

作者：

Mortamais, Marion ^{[1
]}

Gutierrez, Laure-Anne ^{[1
]}

Balem, Marianne ^{[1
]}

Le Bars, Emmanuelle ^{[2
]}

de Champfleur, Nicolas Menjot ^{[2
]}

Bouyahia, Ali ^{[3
]}

Chupin, Marie ^{[3
]}

Perus, Lisa ^{[1
,4
,5
]}

Fisher, Clara ^{[4
]}

Vellas, Bruno ^{[6
,7
,8
]}

Andrieu, Sandrine ^{[6
,7
,9
]}

Mangin, Jean-Francois ^{[4
]}

Berr, Claudine ^{[1
]}

Gabelle, Audrey ^{[1
,5
]}

机构：

[1] Univ Montpellier, Inst Neurosci Montpellier INM, INSERM, Montpellier, France

[2] Hosp & Univ Montpellier, Inst Imagerie Fonctionnelle Humaine I2FH, Montpellier, France

[3] Sorbonne Univ, Inst Cerveau & Moelle Epiniere, ICM, INSERM,UPMC, Paris, France

[4] Univ Paris Saclay, CNRS, CATI, CEA,Neurospin, Gif Sur Yvette, France

[5] Gui Chauliac Hosp, Dept Neurol, Memory Resources & Res Ctr, Montpellier, France

[6] INSERM, UMR 1027, Toulouse, France

[7] Univ Toulouse III, Toulouse, France

[8] Hosp & Univ Toulouse, Dept Geriatr, Toulouse, France

[9] Hosp & Univ Toulouse, Dept Epidemiol & Publ Hlth, Toulouse, France

来源：

NEUROBIOLOGY OF AGING | 2022年 / 113卷

关键词：

Cerebral sulci; Neuroimaging biomarkers; Cognitive decline; Older adults; ALZHEIMERS-DISEASE; BRAIN; PERFORMANCE; NEUROGRANIN; AGE; PARTICIPANTS; IMPAIRMENT; PATHOLOGY; DEMENTIA; AD;

D O I：

10.1016/j.neurobiolaging.2022.02.003

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

To determine whether sulcal morphology can predict changes in cognition, we investigated the relationship between width of 20 cerebral sulci and cognitive decline. Sulcal width was measured in T1-weighted MRI images at baseline in 433 adults aged >= 70 years with memory complaints from the MRI-Multidomain Alzheimer Preventive Trial study. Cognition was evaluated at baseline, 6, 12, 24, and 36 months of follow-up with a composite Z score. The composite score variations over time relative to the baseline sulcal width were assessed using linear mixed regression models. We observed a positive association between a greater decline in cognitive composite score and the width of the superior and the anterior inferior temporal sulci, and the cingulate anterior sulcus of the left hemisphere. Sulcal widening in the lateral temporal and the cingulate anterior areas might predict cognitive decline in individuals with memory complaints. (c) 2022 Elsevier Inc. All rights reserved.

引用

页码：84 / 94

页数：11

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