Genetics of Autism Spectrum Disorder: An Update

被引：4

作者：

Malik, Salma ^{[1
]}

Khan, Yasser Saeed ^{[2
]}

Sahl, Robert ^{[3
]}

Elzamzamy, Khalid ^{[4
]}

Nazeer, Ahsan ^{[1
]}

机构：

[1] Sidra Med, Child & Adolescent Psychiat Div, Doha, Qatar

[2] Hamad Med Corp, Child & Adolescent Mental Hlth Serv, Doha, Qatar

[3] Hartford Healthcare, Inst Living, Hartford, CT USA

[4] Hamad Med Corp, Doha, Qatar

来源：

PSYCHIATRIC ANNALS | 2019年 / 49卷 / 03期

关键词：

DEVELOPMENTAL-DISABILITIES; MUTATIONS; CHILDREN; RISK; TWIN;

D O I：

10.3928/00485713-20190212-01

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is characterized by a heterogeneous constellation of deficits in social communication and reciprocity along with restrictive, repetitive patterns of behavior. ASD is among the most heritable mental disorders with twin concordance rates ranging between 77% and 95% among monozygotic twins. Advances have been made in understanding the neurobiological mechanisms and genetic underpinnings of ASD. Over the past decades, studies have identified a role for both common and rare genetic variations contributing to autism. In this article, we review the genetics of ASD and highlight findings in the field.

引用

页码：109 / 114

页数：6

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