Nickel chloride-catalyzed one-pot three-component synthesis of pyrazolophthalazinyl spirooxindoles

被引：76
|
作者：
Zhang, Xiao-Nan [1 ]
Li, Yong-Xiao [1 ]
Zhang, Zhan-Hui [1 ]
机构：
[1] Hebei Normal Univ, Coll Chem & Mat Sci, Shijiazhuang 050016, Peoples R China
来源：
TETRAHEDRON | 2011年 / 67卷 / 38期
基金：
中国国家自然科学基金;
关键词：
Nickel chloride; Pyrazolophthalazinyl spirooxindoles; Multicomponent reaction; One-pot; Polyethylene glycol; MAGNETIC FE3O4 NANOPARTICLES; SOLVENT-FREE CONDITIONS; GREEN REACTION MEDIA; POLYETHYLENE-GLYCOL; ENANTIOSELECTIVE SYNTHESIS; MULTICOMPONENT REACTIONS; POLY(ETHYLENE GLYCOL); EFFICIENT CATALYST; NATURAL-PRODUCTS; ARYL HALIDES;
D O I：
10.1016/j.tet.2011.07.002
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A direct and efficient approach for the preparation of pyrazolophthalazinyl spirooxindoles has been developed through one-pot three-component reaction of easily available isatin, malononitrile or cyanoacetic ester, and phthalhydrazide catalyzed by nickel chloride in polyethylene glycol 600. Desired products were obtained in high to excellent yields using a simple workup procedure. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7426 / 7430
页数：5
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