Isolation by HPLC and characterisation of the bioactive fraction of New Zealand manuka (Leptospermum scoparium) honey

被引：195

作者：

Adams, Christopher. J. ^{[1
]}

Boult, Cherie H. ^{[1
]}

Deadman, Benjamin J. ^{[1
]}

Farr, Judie M. ^{[1
]}

Grainger, Megan N. C. ^{[1
]}

Manley-Harris, Merilyn ^{[1
]}

Snow, Melanie J. ^{[1
]}

机构：

[1] Univ Waikato, Dept Chem, Hamilton, New Zealand

来源：

CARBOHYDRATE RESEARCH | 2008年 / 343卷 / 04期

关键词：

New Zealand manuka honey; bioactive fraction; methylglyoxal;

D O I：

10.1016/j.carres.2007.12.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using HPLC a fraction of New Zealand manuka honey has been isolated, which gives rise to the non-peroxide antibacterial activity. This fraction proved to be methylglyoxal, a highly reactive precursor in the formation of advanced glycation endproducts (AGEs). Methylglyoxal concentrations in 49 manuka and 34 non-manuka honey samples were determined using a direct detection method and compared with values obtained using standard o-phenylenediamine derivatisation. Concentrations obtained using both the methods were similar and varied from 38 to 828 mg/kg. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：651 / 659

页数：9

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