Impact of IFN-Free and IFN-Based Treatment on Blood Myeloid Dendritic Cell, Monocyte, Slan-DC, and Activated T Lymphocyte Dynamics during HCV Infection

被引：2

作者：

Vita, Serena ^{[1
,2
]}

Zuccal, Paola ^{[1
]}

Savinelli, Stefano ^{[1
]}

Mascia, Claudia ^{[1
]}

Rossi, Raffaella ^{[1
]}

Schiavone, Francesco ^{[3
]}

Marocco, Raffaella ^{[2
]}

Tieghi, Tiziana ^{[2
]}

Iannetta, Marco ^{[1
]}

Nijhawan, Parni ^{[1
]}

Zingaropoli, Maria Antonella ^{[1
]}

d'Ettore, Gabriella ^{[1
]}

Vullo, Vincenzo ^{[1
]}

Mastroianni, Claudio Maria ^{[1
]}

Lichtner, Miriam ^{[1
]}

机构：

[1] Sapienza Univ Rome, Dept Publ Hlth & Infect Dis, Rome, Italy

[2] SM Goretti Hosp, Latina, Italy

[3] Sapienza Univ Rome, Dept Mol Med, Rome, Italy

来源：

JOURNAL OF IMMUNOLOGY RESEARCH | 2020年 / 2020卷

关键词：

HEPATITIS-C; GENOTYPE; IMMUNE-RESPONSES; TRIPLE THERAPY; LIVER FIBROSIS; INTERFERON; BOCEPREVIR; TELAPREVIR; RIBAVIRIN; INNATE;

D O I：

10.1155/2020/2781350

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chronic hepatitis C virus infection leads to the activation of innate immunity, a key component in HCV fibrosis. In the past, the use of IFN-based treatment regimens did not permit an adequate evaluation of the impact of HCV clearance on immune cells, because of their antiviral and immunomodulatory properties. The recent development of direct-acting antiviral (DAA) therapy, which is associated with high rates of sustained virological response, enables a more accurate analysis of the immunological modifications following HCV eradication. We studied the dynamics of blood myeloid dendritic cells, monocytes, slan-DCs, and T lymphocytes during IFN-free and IFN-based regimens in hepatitis C virus infection.

引用

页数：11