Novel diterpenes with cytotoxic, anti-malarial and anti-tuberculosis activities from a brown alga Dictyota sp.

被引：30
|
作者：
Jongaramruong, J. [1 ]
Kongkam, N. [1 ]
机构：
[1] Burapha Univ, Fac Sci, Dept Chem, Bangasaen 20131, Chonburi, Thailand
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2007年 / 9卷 / 08期
关键词：
dictyota; diterpene; NCI-H187; HSV-1; anti-malarial;
D O I：
10.1080/10286020701189203
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new diterpenes, (1E,2R*,3R*,4S*,6E,18S*)-4,18-dihydroxydictyolactone (1) and 8 alpha,11-dihydroxypachydictyol A (2), together with fucoxanthin (3) and a known diterpene 4-hydroxycrenulatane (4) were isolated from the methanol extract of the brown alga Dictyota sp. collected from Bangsaen Beach, Thailand. Their structures were determined by spectroscopic data. The relative stereochemistry of 1 was established by NOE difference and NOESY experiments. Compound 1 showed weak anti-tuberculosis activity while 2 displayed strong cytotoxicity against the NCI-H187 cell line, and potent anti-malarial activity. In addition, 3 was active against HSV-1 and malarial parasites.
引用
收藏
页码：743 / 751
页数：9
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