pH-switchable strand orientation in peptide assemblies

被引：21
|
作者：
Schnarr, NA [1 ]
Kennan, AJ [1 ]
机构：
[1] Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA
来源：
ORGANIC LETTERS | 2005年 / 7卷 / 03期
关键词：
D O I：
10.1021/ol047720l
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The design of antiparallel coiled-coil heterotrimeris with singly mismatched electrostatic interfaces is reported. The new complexes exhibit expected properties for well-formed coiled-coils and have stabilities comparable to those of parallel analogues. The mismatch-ad interface facilitates switching from a parallel to antiparallel complex by pH-triggered strand exchange.
引用
收藏
页码：395 / 398
页数：4
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