ERG11 Gene Mutations and MDR1 Upregulation Confer Pan-Azole Resistance in Candida tropicalis Causing Disseminated Candidiasis in an Acute Lymphoblastic Leukemia Patient on Posaconazole Prophylaxis

被引：1

作者：

You, Liangshun ^{[1
]}

Qian, Wenbin ^{[1
]}

Yang, Qing ^{[2
]}

Mao, Liping ^{[1
]}

Zhu, Li ^{[1
]}

Huang, Xianbo ^{[1
]}

Jin, Jie ^{[1
]}

Meng, Haitao ^{[1
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 1, Dept Hematol, Coll Med, Hangzhou, Zhejiang, Peoples R China

[2] Zhejiang Univ, Affiliated Hosp 1, Coll Med, Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou, Zhejiang, Peoples R China

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2017年 / 61卷 / 07期

基金：

中国国家自然科学基金;

关键词：

ERG11; mutation; MDR1; azole resistance; Candida tropicalis; candidiasis; posaconazole; acute leukemia; FLUCONAZOLE RESISTANCE; ANTIFUNGAL PROPHYLAXIS; SUSCEPTIBILITY; INFECTIONS;

D O I：

10.1128/AAC.02496-16

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In this study, we present a rare case of fatal breakthrough Candida tropicalis infection in a patient with acute lymphoblastic leukemia (ALL) while on posaconazole prophylaxis. Then, we explore the mechanisms underlying azole resistance by focusing on enhanced efflux pumps and changes in the azole target enzyme Erg11p, which was encoded by the ERG11 gene. Our study demonstrates that Y132C substitution of Erg11p combined with MDR1 overexpression may be the panazole resistance mechanisms in Candida tropicalis.

引用

页数：5

共 2 条

[1] MDR1 overexpression combined with ERG11 mutations induce high-level fluconazole resistance in Candida tropicalis clinical isolates
Jin, Longyang
Cao, Zhuorui
Wang, Qi
Wang, Yichen
Wang, Xiaojuan
Chen, Hongbin
Wang, Hui
BMC INFECTIOUS DISEASES, 2018, 18
[2] MDR1 overexpression combined with ERG11 mutations induce high-level fluconazole resistance in Candida tropicalis clinical isolates
Longyang Jin
Zhuorui Cao
Qi Wang
Yichen Wang
Xiaojuan Wang
Hongbin Chen
Hui Wang
BMC Infectious Diseases, 18

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