The Predikin webserver: improved prediction of protein kinase peptide specificity using structural information

被引：26
|
作者：
Saunders, Neil F. W. [1 ]
Kobe, Bostjan [2 ,3 ]
机构：
[1] Univ Queensland, Sch Mol & Microbial Sci, Brisbane, Qld 4072, Australia
[2] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia
[3] Univ Queensland, Ctr Funct & Appl Genom, Brisbane, Qld 4072, Australia
来源：
NUCLEIC ACIDS RESEARCH | 2008年 / 36卷
基金：
澳大利亚研究理事会; 英国医学研究理事会;
关键词：
D O I：
10.1093/nar/gkn279
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Predikin webserver allows users to predict substrates of protein kinases. The Predikin system is built from three components: a database of protein kinase substrates that links phosphorylation sites with specific protein kinase sequences; a perl module to analyse query protein kinases and a web interface through which users can submit protein kinases for analysis. The Predikin perl module provides methods to (i) locate protein kinase catalytic domains in a sequence, (ii) classify them by type or family, (iii) identify substrate-determining residues, (iv) generate weighted scoring matrices using three different methods, (v) extract putative phosphorylation sites in query substrate sequences and (vi) score phosphorylation sites for a given kinase, using optional filters. The web interface provides user-friendly access to each of these functions and allows users to obtain rapidly a set of predictions that they can export for further analysis. The server is available at http://predikin.biosci.uq.edu.au.
引用
收藏
页码：W286 / W290
页数：5
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