TiCl4: An efficient catalyst for one-pot synthesis of 1,2-dihydro-1-aryl-naphtho-[1,2-e][1,3]oxazin-3-one derivatives and their drug score analysis

Multi-component, economical and efficient synthesis of 1,2-dihydro-1-aryl-naphtho[1,2-e][1,3]-oxazin-3-one derivatives (4a-k) with an excellent yield is described through a one-pot condensation of beta-naphthol, aromatic aldehydes and urea in presence of catalytic amount of TiCl4 (10 mol%) under conventional heating and microwave irradiation. The role of catalyst in the conversion of reactants to the final compounds is described. All the compounds have been characterized by spectral (IR, H-1, C-13 NMR and Mass) and analytical data. The pharmacological parameters of title compounds were also analyzed for their bioavailability by Osiris property explorer. (C) 2013 Production and hosting by Elsevier B.V. on behalf of King Saud University.