Cytotoxic mycoepoxydiene derivatives from an endophytic fungus Phomopsis sp isolated from Hydnocarpus anthelminthicus

被引：39

作者：

Prachya, Surasak

Wiyakrutta, Suthep

Sriubolmas, Nongluksna

Ngamrojanavanich, Nattaya

Mahidol, Chulabhorn

Ruchirawat, Somsak

Kittakoop, Prasat

机构：

[1] Chulabhorn Res Inst, Bangkok 10210, Thailand

[2] Chulabhorn Grad Inst, Bangkok 10210, Thailand

[3] Chulalongkorn Univ, Fac Sci, Program Biotechnol, Bangkok, Thailand

[4] Mahidol Univ, Fac Sci, Dept Microbiol, Bangkok 10400, Thailand

[5] Chulalongkorn Univ, Fac Pharmaceut Sci, Dept Microbiol, Bangkok, Thailand

[6] Chulalongkorn Univ, Fac Sci, Dept Chem, Bangkok, Thailand

[7] Mahidol Univ, Inst Sci & Technol Res & Dev, Chulabhorn Res Ctr, Bangkok 10700, Thailand

来源：

PLANTA MEDICA | 2007年 / 73卷 / 13期

关键词：

D O I：

10.1055/s-2007-990240

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Mycoepoxydiene (1) and derivatives, deacetylmycoepoxydiene (2) and 2,3-dihydromycoepoxydiene (3), were isolated from a broth extract of the endophytic fungus, Phomopsis sp., which was isolated from a Thai medicinal plant, Hydnocarpus anthelminthicus. Compounds 1 and 2 exhibited potent cytotoxic activity, while a dihydro derivative 3 was inactive. The present work suggests that the alpha,beta-unsaturated lactone moiety in mycoepoxydienes might be responsible for the cytotoxicity.

引用

页码：1418 / 1420

页数：3

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