UGT inhibition studies in the presence or absence of alamethicin: evaluation of UGT1A1 and UGT2B7 inhibition in hlm and recombinant enzymes

被引:0
|
作者
Ejaz, Sadaff [1 ]
Yerino, Phyllis [1 ]
Babara, Joanna [1 ]
Grbac, Robert [1 ]
Ogilvie, Brain W. [1 ]
Buckley, David B. [1 ]
机构
[1] XenoTech LLC, Lenexa, KS USA
关键词
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
P132
引用
收藏
页码:90 / 91
页数:2
相关论文
共 50 条
  • [1] VALIDATED ASSAY FOR THE EVALUATION OF UGT1A1 AND UGT2B7 INHIBITION USING ESTRADIOL AS PROBE SUBSTRATE
    Chen, Weiqi
    Gan, Jinping
    He, Kan
    Shyu, Wen-chyi
    Rodrigues, A. David
    DRUG METABOLISM REVIEWS, 2008, 40 : 102 - 102
  • [2] Limited influence of UGT1A1*28 and no effect of UGT2B7*2 polymorphisms on UGT1A1 or UGT2B7 activities and protein expression in human liver microsomes
    Peterkin, Vincent C.
    Bauman, Jonathan N.
    Goosen, Theunis C.
    Menning, Lee
    Man, Michael Z.
    Paulauskis, Joseph D.
    Williams, J. Andrew
    Myrand, Scott P.
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2007, 64 (04) : 458 - 468
  • [3] Genetic variations in UGT1A1 and UGT2B7 and endometrial cancer risk
    McGrath, Monica
    Lepine, Johanie
    Lee, I-Min
    Villeneuve, Lyne
    Buring, Julie
    Guillemette, Chantal
    De Vivo, Immaculata
    PHARMACOGENETICS AND GENOMICS, 2009, 19 (03): : 239 - 243
  • [4] Involvement of human hepatic UGT1A1, UGT2B4, and UGT2B7 in the glucuronidation of carvedilol
    Ohno, A
    Saito, Y
    Hanioka, N
    Jinno, H
    Saeki, M
    Ando, M
    Ozawa, S
    Sawada, J
    DRUG METABOLISM AND DISPOSITION, 2004, 32 (02) : 235 - 239
  • [5] Stereoselective metabolism of racemic carvedilol by UGT1A1 and UGT2B7, and effects of mutation of these enzymes on glucuronidation activity
    Takekuma, Yoh
    Takenaka, Toru
    Yamazaki, Koujiro
    Ueno, Kazuyuki
    Sugawara, Mitsuru
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2007, 30 (11) : 2146 - 2153
  • [6] Two UGT enzymes, UGT1A3 and UGT2B7, are involved in the metabolism of tesaglitazar (GALIDA™)
    Andersson, TB
    Åhlgren, A
    Masimirembwa, CM
    DRUG METABOLISM REVIEWS, 2004, 36 : 131 - 131
  • [7] Role of HNF-1A in the regulation of UGT1A1, UGT1A9 and UGT2B7 MRNA expression.
    Mirkov, S
    Innocenti, F
    Liu, W
    Chen, PX
    Ramirez, J
    Undevia, SD
    Das, S
    Ratain, MJ
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2005, 77 (02) : P61 - P61
  • [8] The Inhibitory Effect of 20(S)-Protopanaxatriol (ppt) Towards UGT1A1 and UGT2B7
    He, Ya-Jun
    Fang, Zhong-Ze
    Ge, Guang-Bo
    Jiang, Peng
    Jin, Hui-Zi
    Zhang, Wei-Dong
    Yang, Ling
    PHYTOTHERAPY RESEARCH, 2013, 27 (04) : 628 - 632
  • [9] Determining the Effects of the UGT1A1*28 and UGT2B7*2 Polymorphisms on the Production of Ethyl Glucuronide In Vivo
    Petrie, Matt
    Smith, Andy
    Wu, Alan
    Lynch, Kara
    AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2012, 138 (03) : 463 - 463
  • [10] Glucuronidation of estrone and 16α-hydroxyestrone by human UGT enzymes: The key roles of UGT1A10 and UGT2B7
    Kallionpaa, Roope A.
    Jarvinen, Erkka
    Finel, Moshe
    JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2015, 154 : 104 - 111