The Pan-Deacetylase Inhibitor Panobinostat Downregulates HIF-1α and VEGF and, Synergizes With Everolimus In Hodgkin Lymphoma Cell Lines

被引:4
|
作者
Lemoine, Manuela [1 ]
Buglio, Daniela [1 ]
Jona, Adam [1 ]
Derenzini, Enrico [1 ]
Medeiros, L. Jeffrey [2 ]
Berry, Donald A. [3 ]
Younes, Anas [1 ]
机构
[1] Univ Texas MD Anderson Canc Ctr, Dept Lymphoma & Myeloma, Houston, TX 77030 USA
[2] Univ Texas MD Anderson Canc Ctr, Dept Heniatopathol, Houston, TX 77030 USA
[3] Univ Texas MD Anderson Canc Ctr, Div Quantitat Sci, Houston, TX 77030 USA
关键词
D O I
10.1182/blood.V116.21.2851.2851
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:1174 / 1175
页数:2
相关论文
共 39 条
  • [1] The pan-deacetylase inhibitor panobinostat induces cell death and synergizes with everolimus in Hodgkin lymphoma cell lines
    Lemoine, Manuela
    Derenzini, Enrico
    Buglio, Daniela
    Medeiros, L. Jeffrey
    Davis, R. Eric
    Zhang, Jiexin
    Ji, Yuan
    Younes, Anas
    BLOOD, 2012, 119 (17) : 4017 - 4025
  • [2] The pan-deacetylase inhibitor panobinostat suppresses the expression of oncogenic miRNAs in hepatocellular carcinoma cell lines
    Henrici, Alexander
    Montalbano, Roberta
    Neureiter, Daniel
    Krause, Michael
    Stiewe, Thorsten
    Slater, Emily Prentice
    Quint, Karl
    Ocker, Matthias
    Di Fazio, Pietro
    MOLECULAR CARCINOGENESIS, 2015, 54 (08) : 585 - 597
  • [3] Inhibition of DNA methyltransferase activity and expression by treatment with the pan-deacetylase inhibitor panobinostat in hepatocellular carcinoma cell lines
    Zopf, Steffen
    Ocker, Matthias
    Neureiter, Daniel
    Alinger, Beate
    Gahr, Susanne
    Neurath, Markus F.
    Di Fazio, Pietro
    BMC CANCER, 2012, 12
  • [4] Inhibition of DNA methyltransferase activity and expression by treatment with the pan-deacetylase inhibitor panobinostat in hepatocellular carcinoma cell lines
    Steffen Zopf
    Matthias Ocker
    Daniel Neureiter
    Beate Alinger
    Susanne Gahr
    Markus F Neurath
    Pietro Di Fazio
    BMC Cancer, 12
  • [5] The Histone Deacetylase Inhibitor LBH589 (Panobinostat) Modulates the Crosstalk of Lymphocytes with Hodgkin Lymphoma Cell Lines
    Klein, Jan M.
    Henke, Alexander
    Sauer, Maike
    Bessler, Martina
    Reiners, Katrin S.
    Engert, Andreas
    Hansen, Hinrich P.
    von Strandmann, Elke Pogge
    PLOS ONE, 2013, 8 (11):
  • [6] Downregulation of HMGA2 by the pan-deacetylase inhibitor panobinostat is dependent on hsa-let-7b expression in liver cancer cell lines
    Di Fazio, Pietro
    Montalbano, Roberta
    Neureiter, Daniel
    Alinger, Beate
    Schmidt, Ansgar
    Merkel, Anna Lena
    Quint, Karl
    Ocker, Matthias
    EXPERIMENTAL CELL RESEARCH, 2012, 318 (15) : 1832 - 1843
  • [7] Preliminary evidence of disease response to the pan deacetylase inhibitor panobinostat (LBH589) in refractory Hodgkin Lymphoma
    Dickinson, Michael
    Ritchie, David
    DeAngelo, Daniel J.
    Spencer, Andrew
    Ottmann, Oliver G.
    Fischer, Thomas
    Bhalla, Kapil N.
    Liu, Angela
    Parker, Katie
    Scott, Jeffrey W.
    Bishton, Mark
    Prince, H. Miles
    BRITISH JOURNAL OF HAEMATOLOGY, 2009, 147 (01) : 97 - 101
  • [8] Phase II study of oral panobinostat (LBH589), a potent pan-deacetylase inhibitor, in patients with refractory Cutaneous T-cell Lymphoma (CTCL)
    Duvic, M.
    Vanaclocha, F.
    Bernengo, M. G.
    Okada, C.
    Breneman, D.
    Zinzani, P. L.
    Zhang, L.
    Bopp, K.
    Laird, G.
    Hirawat, S.
    Prince, M.
    JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (15)
  • [9] Histological expression of angiogenic factors: VEGF, PDGFRα, and HIF-1α in Hodgkin lymphoma
    Passam, Freda H.
    Alexandrakis, Michael G.
    Kafousi, Maria
    Fotinou, Marianthi
    Darivianaki, Katerina
    Tsirakis, George
    Roussou, Paraskevi A.
    Stathopoulos, Efstathios N.
    Siafakas, Nikolaos M.
    PATHOLOGY RESEARCH AND PRACTICE, 2009, 205 (01) : 11 - 20
  • [10] The pan deacetylase inhibitor panobinostat inhibits growth of human burkitt's lymphoma cell line (Raji)
    Onen, Hacer Ilke
    Dogan, Irem
    Ergin, Volkan
    Konac, Ece
    Ekmekci, Abdullah
    Menevse, Adnan
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2010, 26 : S60 - S60