Design and synthesis of phosphotyrosine mimetics

被引：14
|
作者：
Yan, Z
Kahn, M
Qabar, M
Urban, J
Kim, HO
Blaskovich, MA
机构：
[1] Molecumet Ltd, Bellevue, WA 98005 USA
[2] Univ Washington, Dept Pathol, Seattle, WA 98195 USA
[3] Pacific NW Res Inst, Seattle, WA 98122 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 12期
关键词：
D O I：
10.1016/S0960-894X(03)00253-1
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Selective inhibitors of protein tyrosine phosphatases (PTPases) are of great interest as therapeutic agents and research tools. Several phenylalanine derivatives (1, 2) designed as phosphotyrosine mimetics or irreversible active site inhibitors were successfully synthesized, then incorporated into a combinatorial,library based on a peptidomimetic beta-strand template. (C) 2003 Elsevier Science Ltd. All rights reserved.
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收藏
页码：2083 / 2085
页数：3
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