The use of coagulation factor concentrates for perioperative bleeding management - a global perspective

被引：5
|
作者：
Grottke, Oliver [1 ]
Callum, Jeannie [2 ,3 ,4 ]
Cushing, Melissa M. [5 ,6 ]
Haas, Thorsten [7 ]
机构：
[1] RWTH Aachen Univ Hosp, Dept Anesthesiol, Aachen, Germany
[2] Sunnybrook Hlth Sci Ctr, Dept Lab Med & Mol Diagnost, Toronto, ON, Canada
[3] Univ Hlth Network, Lab Med Program, Toronto, ON, Canada
[4] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada
[5] Weill Cornell Med, Dept Pathol & Lab Med, New York, NY USA
[6] Weill Cornell Med, Dept Anesthesiol, New York, NY USA
[7] Zurich Univ Childrens Hosp, Dept Pediat Anesthesia, Steinwiesstr 75, CH-8032 Zurich, Switzerland
来源：
TRANSFUSION | 2020年 / 60卷 / 04期
基金：
加拿大健康研究院;
关键词：
PROTHROMBIN COMPLEX CONCENTRATE; CARDIAC-SURGERY; FACTOR-XIII; FIBRINOGEN; COAGULOPATHY; EFFICACY; REVERSAL; PLACEBO; SAFETY; RISK;
D O I：
10.1111/trf.15749
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
KEY IDEAS The use of purified, pathogen-reduced coagulation factor concentrates instead of a ratio-driven transfusion protocol using plasma, platelets, or cryoprecipitate may offer a faster, safer, and more specific approach to significantly increase the concentration of coagulation factors in bleeding patients. Available products, on-label indications, price, and approach to laboratory monitoring differ considerably worldwide. Although evidence regarding optimal thresholds and dose of coagulation factor concentrates to treat massive perioperative bleeding is still limited, recently multiple high-quality published trials with promising results have been published globally.
引用
收藏
页码：663 / 666
页数：4
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