Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients

被引：4

作者：

Gutierrez, Ana ^{[1
,2
,3
]}

Zapater, Pedro ^{[2
,3
,4
,5
]}

Ricart, Elena ^{[3
,6
]}

Gonzalez-Vivo, Maria ^{[7
]}

Gordillo, Jordi ^{[8
]}

Olivares, David ^{[9
]}

Vera, Isabel ^{[10
]}

Manosa, Miriam ^{[3
,11
]}

Gisbert, Javier P. ^{[3
,12
]}

Aguas, Mariam ^{[3
,13
]}

Sanchez-Rodriguez, Eugenia ^{[14
]}

Bosca-Watts, Maia ^{[15
]}

Laredo, Viviana ^{[16
]}

Camps, Blau ^{[17
]}

Marin-Jimenez, Ignacio ^{[18
,19
]}

Zabana, Yamile ^{[3
,20
]}

Martin-Arranz, Maria Dolores ^{[21
]}

Munoz, Roser ^{[1
]}

Navarro, Merce ^{[22
]}

Sierra, Eva ^{[23
]}

Madero, Lucia ^{[24
]}

Vela, Milagros ^{[25
]}

Perez-Calle, Jose Lazaro ^{[26
]}

Sainz, Empar ^{[27
]}

Calvet, Xavier ^{[3
,28
]}

Arias, Lara ^{[29
]}

Morales, Victor ^{[30
]}

Bermejo, Fernando ^{[31
,32
]}

Fernandez-Salazar, Luis ^{[33
]}

Van Domselaar, Manuel ^{[34
]}

De Castro, Luisa ^{[35
]}

Rodriguez, Cristina ^{[36
]}

Munoz-Villafranca, Carmen ^{[37
]}

Lorente, Rufo ^{[38
]}

Rivero, Montserrat ^{[39
]}

Iglesias, Eva ^{[40
,41
]}

Herreros, Belen ^{[42
]}

Busquets, David ^{[43
]}

Riera, Joan ^{[44
]}

Martinez-Montiel, Maria Pilar ^{[45
]}

Roldon, Marta ^{[46
]}

Roncero, Oscar ^{[47
]}

Hinojosa, Esther ^{[48
]}

Sierra, Monica ^{[49
]}

Barrio, Jesus ^{[50
]}

De Francisco, Ruth

Huguet, Jose ^{[51
,52
,53
]}

Merino, Olga ^{[54
]}

Carpio, Daniel ^{[55
]}

Ginard, Daniel ^{[56
]}

机构：

[1] Hosp Gen Univ Alicante, Serv Med Digest, Alicante, Spain

[2] Hosp Gen Univ Alicante, IIS Isabial, Alicante, Spain

[3] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain

[4] Hosp Gen Univ Alicante, Unidad Farmacol Clin, Alicante, Spain

[5] Univ Miguel Hernandez, Inst IDIBE, Alacant, Spain

[6] Serv Med Digest Hosp Clin, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain

[7] Hosp del Mar, IMIM Hosp Mar Med Res Inst, Serv Med Digest, Barcelona, Spain

[8] Hosp Santa Creu & Sant Pau, Serv Patol Digest, Barcelona, Spain

[9] Hosp Univ Clin San Carlos, Med Digest, Madrid, Spain

[10] Hosp Univ Puerta Hierro, Serv Aparato Digest, Madrid, Spain

[11] Hosp Badalona Germans Trias & Pujol, Serv Aparato Digest, Badalona, Spain

[12] Univ Autonoma Madrid UAM, Inst Invest Sanitaria Princesa IIS IP, Hosp Univ Princesa, Serv Aparato Digest, Madrid, Spain

[13] Hosp Univ La Fe, Serv Med Digest, Valencia, Spain

[14] Hosp Univ Ramon & Cajal, Serv Med Digest, Madrid, Spain

[15] Hosp Clin Univ Valencia, Serv Med Digest, Valencia, Spain

[16] Hosp Clin Univ Lozano Blesa, Serv Med Digest, Zaragoza, Spain

[17] Hosp Univ Bellvitge, Serv Med Digest, Barcelona, Spain

[18] Hosp Gregorio Maranon, Serv Med Digest, Madrid, Spain

[19] Inst Invest Biomed Gregorio Maranon IiSGM, Gastroenterol Dept, Madrid, Spain

[20] Hosp Univ Mutua Terrassa, Serv Med Digest, Terrassa, Spain

[21] Hosp La Paz, Serv Med Digest, Madrid, Spain

[22] Hosp St Joan Despi Moises Broggi, Serv Med Digest, Barcelona, Spain

[23] Hosp Univ Miguel Servert, Serv Med Digest, Zaragoza, Spain

[24] Hosp Gen Univ Elche, Serv Med Digest, Elche, Spain

[25] Hosp Nuestra Senora Candelaria, Serv Med Digest, Santa Cruz De Tenerife, Spain

[26] Hosp Univ Fdn Alcorcon, Serv Med Digest, Madrid, Spain

[27] Hosp St Joan Deu Althaia, Serv Med Digest, Manresa, Spain

[28] Univ Autonoma Barcelona UAB, Inst Univ Parc Tauli, Hosp Sabadell, Unitat Malalties Digest, Barcelona, Spain

[29] Hosp Univ Burgos, Serv Med Digest, Burgos, Spain

[30] Hosp Gen Granollers, Serv Med Digest, Barcelona, Spain

[31] Hosp Fuenlabrada, Serv Med Digest, Fuenlabrada, Spain

[32] IIS Hosp Paz IdiPaz Madrid, Madrid, Spain

[33] Hosp Clin Valladolid, Serv Med Digest, Madrid, Spain

[34] Hosp Torrejon Ardoz, Serv Med Digest, Madrid, Spain

[35] SERGAS UVIG, IIS Galicia Sur, Xerencia Xest Integrada Vigo SERGAS, Dept Gastroenterol, Vigo, Spain

[36] Complejo Hosp Navarra, Serv Med Digest, Pamplona, Spain

[37] Hosp Univ Basurto, Serv Med Digest, Bilbao, Spain

[38] Hosp Gen Ciudad Real, Serv Med Digest, Ciudad Real, Spain

[39] Hosp Univ Marques Valdecilla & IDIVAL, Serv Med Digest, Santander, Spain

[40] Hosp Univ Reina Sofia, Serv Med Digest, Cordoba, Spain

[41] Inst Maimonides Invest Biomed Cordoba IMIBIC, Cordoba, Spain

[42] Hosp Marina Baixa, Serv Med Digest, Villajoyosa, Spain

[43] Hosp Girona Dr Trueta ICO, Serv Med Digest, Girona, Spain

[44] Hosp Univ Son LLatzer, Serv Med Digest, Palma de Mallorca, Spain

[45] Hosp 12 Octubre, Serv Med Digest, Madrid, Spain

[46] Hosp San Jorge, Serv Cirugia Gen & Aparato Digest, Huesca, Spain

[47] Hosp Gen La Mancha Ctr, Serv Med Digest, Ciudad Real, Spain

[48] Hosp Manises, Serv Med Digest, Valencia, Spain

[49] Complejo Asistencial Univ Leon, Serv Med Digest, Leon, Spain

[50] Hosp Univ Rio Hortega, Valladolid, Spain

来源：

FRONTIERS IN MEDICINE | 2022年 / 9卷

关键词：

immigrant; phenotype; biologics; inflammatory bowel disease; Crohn's disease; ulcerative colitis; INFLAMMATORY-BOWEL-DISEASE; NON-HISPANIC WHITES; ULCERATIVE-COLITIS; CROHNS-DISEASE; CLINICAL CHARACTERISTICS; ENVIRONMENTAL-FACTORS; AFRICAN-AMERICANS; RISK-FACTORS; PHENOTYPE; EPIDEMIOLOGY;

D O I：

10.3389/fmed.2022.823900

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BackgroundPrevious studies comparing immigrant ethnic groups and native patients with IBD have yielded clinical and phenotypic differences. To date, no study has focused on the immigrant IBD population in Spain. MethodsProspective, observational, multicenter study comparing cohorts of IBD patients from ENEIDA-registry who were born outside Spain with a cohort of native patients. ResultsWe included 13,524 patients (1,864 immigrant and 11,660 native). The immigrants were younger (45 +/- 12 vs. 54 +/- 16 years, p < 0.001), had been diagnosed younger (31 +/- 12 vs. 36 +/- 15 years, p < 0.001), and had a shorter disease duration (14 +/- 7 vs. 18 +/- 8 years, p < 0.001) than native patients. Family history of IBD (9 vs. 14%, p < 0.001) and smoking (30 vs. 40%, p < 0.001) were more frequent among native patients. The most prevalent ethnic groups among immigrants were Caucasian (41.5%), followed by Latin American (30.8%), Arab (18.3%), and Asian (6.7%). Extraintestinal manifestations, mainly musculoskeletal affections, were more frequent in immigrants (19 vs. 11%, p < 0.001). Use of biologics, mainly anti-TNF, was greater in immigrants (36 vs. 29%, p < 0.001). The risk of having extraintestinal manifestations [OR: 2.23 (1.92-2.58, p < 0.001)] and using biologics [OR: 1.13 (1.0-1.26, p = 0.042)] was independently associated with immigrant status in the multivariate analyses. ConclusionsCompared with native-born patients, first-generation-immigrant IBD patients in Spain were younger at disease onset and showed an increased risk of having extraintestinal manifestations and using biologics. Our study suggests a featured phenotype of immigrant IBD patients in Spain, and constitutes a new landmark in the epidemiological characterization of immigrant IBD populations in Southern Europe.

引用

页数：11

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