Metal-Free Regioselective Chloroazidation of Internal Alkynes

被引：7
|
作者：
Huang, Bin [1 ]
Liffert, Raphael [1 ]
Linden, Anthony [1 ]
Gademann, Karl [1 ]
机构：
[1] Univ Zurich, Dept Chem, Winterthurerstr 190, CH-8057 Zurich, Switzerland
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2019年 / 25卷 / 04期
关键词：
alkynes; chloroazidation; metal-free; regioselectivity; VINYL AZIDES; HYDROAZIDATION; 2H-AZIRINES; ACCESS;
D O I：
10.1002/chem.201805320
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A metal-free, room temperature protocol for the regioselective chloroazidation of internal alkynes is disclosed. The reactions of internal alkynes with trimethylsilyl azide (TMSN3) in the presence of 1,3-dichloro-5,5-dimethylhydantoin (DCDMH) afforded the corresponding chloroazidoalkenes in good yields. This reaction has good functional group tolerance and is operationally simple.
引用
收藏
页码：981 / 984
页数：4
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