Biogeographical variation in specific IgE recognition of temperate and subtropical grass pollen allergens in allergic rhinitis patients

被引：15

作者：

Kailaivasan, Thina H. ^{[1
]}

Timbrell, Victoria L. ^{[1
]}

Solley, Graham ^{[2
]}

Smith, William B. ^{[3
]}

McLean-Tooke, Andrew ^{[4
]}

van Nunen, Sheryl ^{[5
,6
]}

Smith, Peter ^{[7
]}

Upham, John W. ^{[8
,9
]}

Langguth, Daman ^{[10
]}

Davies, Janet M. ^{[1
,11
]}

机构：

[1] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Sch Biomed Sci, Brisbane, Qld, Australia

[2] Watkins Med Ctr, Brisbane, Qld, Australia

[3] AllergySA, Adelaide, SA, Australia

[4] Sir Charles Gairdner Hosp, Perth, WA, Australia

[5] Royal North Shore Hosp, Sydney, NSW, Australia

[6] Univ Sydney, Sydney, NSW, Australia

[7] Queensland Allergy Serv, Gold Coast, Qld, Australia

[8] Univ Queensland, Brisbane, Qld, Australia

[9] Princess Alexandra Hosp, Brisbane, Qld, Australia

[10] Sullivan Nicolaides Pathol, Brisbane, Qld, Australia

[11] Metro North Hosp & Hlth Serv, Herston, Qld, Australia

来源：

CLINICAL & TRANSLATIONAL IMMUNOLOGY | 2020年 / 9卷 / 02期

基金：

英国医学研究理事会;

关键词：

allergic rhinitis; allergy; cross-inhibition; grass pollen; IgE; PAS N 1; T-CELL RESPONSE; CROSS-REACTIVITY; THUNDERSTORM ASTHMA; MAJOR ALLERGEN; IMMUNOTHERAPY; EPITOPES; RISK;

D O I：

10.1002/cti2.1103

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Objective Globally, grass pollens (GP) are major aeroallergen triggers of allergic rhinitis (AR) and asthma. However, patterns of allergic sensitisation to pollen of temperate (Pooideae: Lolium perenne) and subtropical (Chloridoideae: Cynodon dactylon and Panicoideae: Paspalum notatum) subfamilies in diverse climates remain unclear. This study aims to evaluate the level of allergic sensitisation and IgE specificity for major GP allergens representing the three subfamilies in biogeographically distinct regions. Methods Participants (GP-allergic with AR, 330; non-atopic, 29; other allergies, 54) were recruited in subtropical: Queensland, and temperate: New South Wales, Western and South Australia, regions. Clinical history, skin prick test (SPT), total and specific IgE to GP and purified allergens (ImmunoCAP) were evaluated. Cross-inhibition of sIgE with Pas n 1, Cyn d 1 and Lol p 1 by GP extracts was investigated. Results Queensland participants showed higher sensitisation to P. notatum and C. dactylon than L. perenne GP. sIgE was higher to Pas n 1 and Cyn d 1, and sIgE to Pas n 1 and Cyn d 1 was inhibited more by Panicoideae and Chloridoideae, respectively, than Pooideae GP. Conversely, participants from temperate regions showed highest sensitisation levels to L. perenne GP and Lol p 1, and sIgE to Lol p 1 was inhibited more by Pooideae than other GP. Conclusion Levels and patterns of sensitisation to subtropical and temperate GP in AR patients depended on biogeography. Knowledge of the specificity of sensitisation to local allergens is important for optimal diagnosis and choice of allergen-specific immunotherapy to maximise benefit.

引用

页数：11

共 50 条

[1] Biogeographical variation in IgE specificity and avidity for subtropical and temperate grass pollen allergens; the multicentre cross-sectional Grass Pollen Allergy Survey (GPAS)
Kailaivasan, T.
Timbrell, V
Solley, G.
Smith, W. B.
Mclean-Tooke, A.
Van Nunen, S.
Smith, P. K.
Upham, J. W.
Langguth, D.
Davies, J. M.
ALLERGY, 2018, 73 : 195 - 196
[2] Allergy to subtropical grass pollens compared with temperate grass pollen in patients with allergic rhinitis from a subtropical region
Davies, J.
Li, H.
Towers, M.
Green, M.
Upham, J.
ALLERGY, 2011, 66 : 173 - 174
[3] Regional variation in allergic sensitivity to subtropical and temperate grass pollen allergens; outcomes of the multicentre cross-sectional Grass Pollen Allergy Survey (GPAS)
Davies, J.
Timbrell, V
Reibelt, L.
Simmonds, C.
Solley, G.
Smith, W.
Mclean-Tooke, A.
van Nunen, S.
Smith, P.
Upham, J.
Langguth, D.
EUROPEAN JOURNAL OF IMMUNOLOGY, 2016, 46 : 841 - 841
[4] SPECIFIC IGE IN THE IDENTIFICATION OF ALLERGENS IN ALLERGIC RHINITIS MALAYSIAN PATIENTS
CHOONKOOK, S
TECKSOONG, SL
ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY, 1995, 13 (01): : 23 - 27
[5] Nanofluidic point-of-care IgE test for subtropical grass pollen for rapid diagnosis of allergic rhinitis
Davies, Janet M.
Pralong, Claire
Tickner, Jacob
Timbrell, Victoria
Rodger, Alison
van den Bogaard, Patrick
Rebeaud, Fabien
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2024, 132 (04) : 497 - 504.e3
[6] Back to basics: likelihood ratios for olive and grass pollen specific IgE in seasonal allergic rhinitis
Manzanares, Barbara
Gonzalez, Rafael
Serrano, Pilar
Navas, Ana
Alonso, Corona
Fernandez, Lourdes
Jurado, Aurora
Moreno-Aguilar, Carmen
FRONTIERS IN ALLERGY, 2023, 4
[7] Comparison of Molecular Multiplex and Singleplex Analysis of IgE to Grass Pollen Allergens in Untreated German Grass Pollen-Allergic Patients
Ahlgrim, C.
Gutermuth, J.
Onell, A.
Borres, M. P.
Schaeffner, I
Darsow, U.
Pfab, F.
Brockow, K.
Ring, J.
Behrendt, H.
Jakob, T.
Huss-Marp, J.
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY, 2015, 25 (03) : 190 - 195
[8] Eosinophil cationic protein and specific IgE in serum and nasal mucosa of patients with grass-pollen-allergic rhinitis and asthma
Marcucci, F
Sensi, LG
Migali, E
Coniglio, G
ALLERGY, 2001, 56 (03) : 231 - 236
[9] Changes in specific IgE to single grass pollen allergens in patients undergoing sublingual immunotherapy
Marcucci, F.
Sensi, L.
Incorvaia, C.
Soffia, S.
Scurati, S.
Frati, F.
Di Cara, G.
ALLERGY, 2011, 66 : 623 - 623
[10] 5-grass-pollen SLIT effectiveness in seasonal allergic rhinitis: Impact of sensitization to subtropical grass pollen
van Nunen, Sheryl A.
Burk, Melanie B.
Burton, Pamela K.
Ford, Geoffrey
Harvey, Richard J.
Lozynsky, Alexander
Pickford, Elizabeth
Rimmer, Janet S.
Smart, Joanne
Sutherland, Michael F.
Thien, Francis
Weber, Heinrich C.
Zehnwirth, Harry
Newbigin, Ed
Katelaris, Constance H.
WORLD ALLERGY ORGANIZATION JOURNAL, 2022, 15 (02):

← 1 2 3 4 5 →