Stimuli-responsive controlled drug release from a hollow mesoporous silica sphere/polyelectrolyte multilayer core-shell structure

被引：904
|
作者：
Zhu, YF [1 ]
Shi, JL [1 ]
Shen, WH [1 ]
Dong, XP [1 ]
Feng, JW [1 ]
Ruan, ML [1 ]
Li, YS [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 32期
关键词：
drug delivery; mesoporous materials; multilayers; nanostructures; polyelectrolytes;
D O I：
10.1002/anie.200501500
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Figure Presented) Keeping drugs under control: Hydrothermally stable, hollow mesoporous silica spheres have a high drug storage capacity, and polyelectrolyte multilayers coated on the spheres act as a switch for drug release which is controlled by the pH or ionic strength of the release medium. The picture shows the release of ibuprofen (IBU) from spheres with and without coatings of sodium polystyrene sulfonate (PSS) and poly(allylamine hydrochloride) (PAH). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：5083 / 5087
页数：5
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