Artificial Egg Activation Using Calcium Ionophore

被引：2

作者：

Attia, Ahmed ^{[1
]}

Nicholson, Cara ^{[1
]}

da Silva, Sarah J. Martins ^{[1
]}

机构：

[1] Univ Dundee, Ninewells Hosp & Med Sch, Sch Med, Reprod Med Res Grp, Dundee DD1 9SY, Scotland

来源：

SEMINARS IN REPRODUCTIVE MEDICINE | 2021年 / 39卷 / 05/06期

关键词：

artificial oocyte activation; calcium ionophore; failed fertilization; add-on; ART adjuvant; PHOSPHOLIPASE-C-ZETA; INTRACYTOPLASMIC SPERM INJECTION; ASSISTED OOCYTE ACTIVATION; IMPROVE REPRODUCTIVE OUTCOMES; LOW FERTILIZATION RATES; WW-BINDING-PROTEIN; PLC-ZETA; CA2+ OSCILLATIONS; SUCCESSFUL PREGNANCY; MALE-INFERTILITY;

D O I：

10.1055/s-0041-1742171

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Artificial oocyte activation, most commonly using calcium ionophore, is a treatment add-on utilized to avoid recurrence of abnormally low or total failed fertilization following in vitro fertilization/intracytoplasmic sperm injection. It aims to modify defective physiological processes, specifically calcium-mediated cell signaling that are critical to events required for fertilization. Routine application of artificial oocyte activation is neither required nor recommended; however, it represents an invaluable intervention for a subgroup of patients affected by sperm-related oocyte activation deficiency.

引用

页码：E5 / E11

页数：7

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