Comparison of Immune Responses Elicited by SARS-CoV-2 mRNA and Recombinant Protein Vaccine Candidates

被引:10
|
作者
Wu, Yixin [1 ]
Zhang, Huicong [2 ]
Meng, Liuxian [1 ]
Li, Fusheng [2 ,3 ]
Yu, Changyuan [1 ]
机构
[1] Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing, Peoples R China
[2] Sysvax Inc, Res Dept, Beijing, Peoples R China
[3] Sun Yat sen Biomed Inst Ltd, Vaccine Div, Hong Kong, Peoples R China
来源
FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷
基金
中国国家自然科学基金;
关键词
SARS-CoV-2; protein vaccine; mRNA vaccine; IgG subclass antibodies; cellular immune response; CELL RESPONSES; FCR;
D O I
10.3389/fimmu.2022.906457
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
After the outbreak of COVID-19, billions of vaccines with different types have been administrated, including recombinant protein vaccines and mRNA vaccines. Although both types of SARS-CoV-2 vaccine can protect people from viral infection, their differences in humoral and cellular immune responses are still not clearly understood. In this study, we made a head-to-head comparison between an mRNA vaccine candidate and a recombinant protein vaccine we developed previously. Results demonstrated that both vaccine candidates could elicit high specific binding and neutralizing antibody titers in BALB/c mice, but with bias towards different IgG subtypes. Besides, the mRNA vaccine candidate induces higher cellular immune responses than the recombinant protein vaccine. To date, this is the first reported study to directly compare the immune responses of both arms between SARS-CoV-2 mRNA and recombinant vaccines.
引用
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页数:8
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