AN EFFICIENT SYNTHESIS AND EVALUATION OF ANTITUMOR ACTIVITIES OF FUNCTIONALIZED PYRANO[2,3-b]QUINOLINES

被引：0

作者：

Lin, Wei ^{[1
,2
]}

Zhang, Mengye ^{[1
]}

Wang, Ning ^{[1
]}

Xu, Wentao ^{[1
]}

Shi, Daqing ^{[1
]}

机构：

[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Jiangsu, Peoples R China

[2] Jiangsu Technol Univ, Sch Chem & Environm Engn, Changzhou 213001, Peoples R China

来源：

HETEROCYCLES | 2018年 / 96卷 / 11期

关键词：

ONE-POT SYNTHESIS; BIOLOGICAL EVALUATION; 3-COMPONENT REACTION; QUINOLINE ALKALOIDS; FACILE SYNTHESIS; DERIVATIVES; INHIBITORS; PROTEIN; AGENTS; ACIDS;

D O I：

10.3987/COM-18-13990

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of novel functionalized pyrano[2,3-b]quinoline derivatives via a three-component reaction of 2-chloroquinoline-3-carbaldehydes, malononitrile and 1,3-dicarbonyl compounds under microwave irradiation is described. This protocol has the advantages of high efficiency, mild reaction conditions, a one-pot procedure, and convenient operation. All of these compounds were evaluated for their antiproliferative properties in vitro against hepatic carcinoma cells and several compounds were found to have good activities.

引用

页码：1977 / 1990

页数：14

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