Brain perfusion differences between Parkinson's disease and multiple system atrophy with predominant parkinsonian features

被引:21
|
作者
Matsui, H
Udaka, F
Miyoshi, T
Hara, N
Tamura, A
Oda, M
Kubori, T
Nishinaka, K
Kameyama, M
机构
[1] Sumitomo Hosp, Dept Neurol, Kita Ku, Osaka 5300005, Japan
[2] Sumitomo Hosp, Dept Psychosomat Med, Kita Ku, Osaka 5300005, Japan
[3] Sumitomo Hosp, Dept Radiol, Kita Ku, Osaka 5300005, Japan
关键词
Parkinson's disease; multiple system atrophy with predominant parkinsonian features; three-dimensional sterectactic surface projections (3D-SSP); N-isopropyl-P-123I iodoamphetamine (I-123-IMp) SPECT;
D O I
10.1016/j.parkreldis.2005.01.001
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: The patterns of regional cerebral blood flow in Parkinson's disease and multiple system atrophy remain inconsistent. Objectives: To compare brain perfusion images of I-123-IMP SPECT between Parkinson's disease, multiple system atrophy with predominant parkinsonian features (MSA-P) and controls. Methods: Eighty-two patients with Parkinson's disease, 10 patients with MSA-P and 14 controls were studied. We performed 3D-SSP and volume of interest analysis using I-123-IMP scintigraphy. Results: Occipital perfusion of MSA-P increased compared to that of Parkinson's disease and perfusion in the cerebellum and primary sensorimotor cortex of Parkinson's disease increased compared to that of MSA-P. Perfusion in the putamen of MSA-P decreased compared to that of Parkinson's disease. Conclusion: Our study demonstrated perfusion differences in I-123-IMP SPECT between the two diseases. © 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码:227 / 232
页数:6
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