From theoretical calculations to the enantioselective synthesis of a 1,3,4-trisubstituted Gly-derived 2-azetidinone

被引：10

作者：

Perez-Faginas, Paula ^{[1
]}

Garcia-Lopez, Ibon Alkorta M. Teresa ^{[1
]}

Gonzalez-Muniz, Rosario ^{[1
]}

机构：

[1] CSIC, Inst Quim Med, E-28006 Madrid, Spain

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 02期

关键词：

D O I：

10.1016/j.tetlet.2007.11.099

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Theoretical calculations on the transition states of the cyclization of 2S-chloropropionyl amino acid derivatives to the corresponding beta-lactams have served to explain the high stereoselectivity of the reaction, and have been the driving force to extend the procedure to the preparation of a Gly-derived 1,3,4-trisubstituted 2-azetidinone in enantiopure form. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：215 / 218

页数：4

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