A study of polymer-supported bases for the solution phase synthesis of glycosyl trichloroacetimidates

被引：19
|
作者：
Chiara, JL [1 ]
Encinas, L [1 ]
Díaz, B [1 ]
机构：
[1] CSIC, Inst Quim Organ Gen, E-28006 Madrid, Spain
来源：
TETRAHEDRON LETTERS | 2005年 / 46卷 / 14期
关键词：
carbohydrates; solid-supported reagents; glycosylation;
D O I：
10.1016/j.tetlet.2005.02.055
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Polystyrene-supported strong organic bases are highly efficient reagents for the solution-phase synthesis of glycosyl trichloroacetimidates, affording quantitative yields of pure products in short reaction times after simple filtration and evaporation. Although efficiency of the different bases varies with substrate structure, polymer-bound 1,8-diazabicyclo[5.4.0]undec-7-ene was found to give the best results for all the substrates tested. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2445 / 2448
页数：4
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