Immune response profiling of malignant pleural mesothelioma for diagnostic and prognostic biomarkers

被引:6
|
作者
Creaney, Jenette [1 ,2 ]
Dick, Ian M. [3 ]
Musk, A. W. [4 ,5 ,6 ]
Olsen, Nola J. [7 ]
Robinson, Bruce W. S. [8 ,9 ]
机构
[1] Univ Western Australia, Sch Med & Pharmacol, Natl Ctr Asbestos Related Dis, Perth, WA, Australia
[2] Sir Charles Gairdner Hosp, Australian Mesothelioma Tissue Bank, Hosp Ave, Nedlands, WA, Australia
[3] Univ Western Australia, Sir Charles Gairdner Hosp, Sch Med & Pharmacol, Natl Ctr Asbestos Related Dis, Hosp Ave, Nedlands, WA, Australia
[4] Sir Charles Gairdner Hosp, Dept Resp Med, Hosp Ave, Nedlands, WA, Australia
[5] Univ Western Australia, Sch Populat Hlth, Natl Ctr Asbestos Related Dis, Perth, WA, Australia
[6] Univ Western Australia, Sch Med & Pharmacol, Perth, WA, Australia
[7] Univ Western Australia, Sch Populat Hlth, Perth, WA, Australia
[8] Univ Western Australia, Sch Med & Pharmacol, Natl Ctr Asbestos Related Dis, Perth, WA, Australia
[9] Sir Charles Gairdner Hosp, Dept Resp Med, Hosp Ave, Nedlands, WA, Australia
关键词
Biomarker; immunoreactivity; luminex; mesothelioma; protoarray; DIFFERENTIATION ANTIGEN RAB38/NY-MEL-1; SERUM MESOTHELIN; SIPULEUCEL-T; CANCER; ASBESTOS; CELL; ANTIBODIES;
D O I
10.3109/1354750X.2016.1160429
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The asbestos induced cancer malignant mesothelioma (MM) is difficult to diagnose and has a poor prognosis. MM is an immunological cancer, therefore autoantibodies may be suitable biomarkers and associated with prognosis. We used Protoarray(R) microarrays to determine immune responses to 8798 antigens in 10MM and 10 asbestos exposed controls and developed diagnostic panels using 17 antigens from this. The AUC of these panels were independently tested in these 10MM patients and controls and in a validation group of 36 controls and 35MM patients using luminex assays; none of the antigens identified were validated. Immune responses to RAB38 were associated with a better prognosis.
引用
收藏
页码:551 / 561
页数:11
相关论文
共 50 条
  • [1] PROGNOSTIC BIOMARKERS IN MALIGNANT PLEURAL MESOTHELIOMA
    Mezzapelle, R.
    Miglio, U.
    Rena, O.
    Mercalli, F.
    Veggiani, C.
    Paganotti, A.
    Buosi, R.
    Rinaldi, M.
    Boldorini, R.
    [J]. ANNALS OF ONCOLOGY, 2014, 25
  • [2] Diagnostic biomarkers of malignant pleural mesothelioma
    Rodriguez Portal, Jose Antonio
    [J]. MEDICINA CLINICA, 2009, 133 (12): : 464 - 466
  • [3] Biomarkers and prognostic factors for malignant pleural mesothelioma
    Vigneri, Paolo
    Martorana, Federica
    Manzella, Livia
    Stella, Stefania
    [J]. FUTURE ONCOLOGY, 2015, 11 (24) : 29 - 33
  • [4] Prognostic Biomarkers for Malignant Pleural Mesothelioma Treated with Chemotherapy
    Akgun, Hakan
    Metintas, Selma
    Ak, Guntulu
    Demirkol, Secil
    Aydin, Resat
    Isbilen, Murat
    Gure, Ali
    Metintas, Muzaffer
    [J]. JOURNAL OF THORACIC ONCOLOGY, 2017, 12 (01) : S1369 - S1369
  • [5] Inflammatory Biomarkers as Prognostic Factors for Malignant Pleural Mesothelioma
    Yerigeri, K.
    Morrow, B.
    Steinberg, S. M.
    Sengupta, M.
    Hassan, R.
    Puthiamadathil, J.
    [J]. JOURNAL OF THORACIC ONCOLOGY, 2023, 18 (11) : S388 - S388
  • [6] Diagnostic and prognostic biomarkers for malignant mesothelioma: an update
    Chen, Zhongjian
    Gaudino, Giovanni
    Pass, Harvey I.
    Carbone, Michele
    Yang, Haining
    [J]. TRANSLATIONAL LUNG CANCER RESEARCH, 2017, 6 (03) : 259 - 269
  • [7] Prognostic value of several biomarkers for the patients with malignant pleural mesothelioma
    Liu, Hui
    Wu, Licun
    Ji, Kai
    Wang, Wei
    [J]. TUMOR BIOLOGY, 2015, 36 (10) : 7375 - 7384
  • [8] Matrix Metalloproteinases Polymorphisms as Prognostic Biomarkers in Malignant Pleural Mesothelioma
    Strbac, Danijela
    Goricar, Katja
    Dolzan, Vita
    Kovac, Viljem
    [J]. DISEASE MARKERS, 2017, 2017
  • [9] A critical update on prognostic and predictive biomarkers in malignant pleural mesothelioma
    Ghanim B.
    Hoda M.A.
    Klikovits T.
    Dome B.
    Grusch M.
    Filipits M.
    Klepetko W.
    Berger W.
    Hegedus B.
    [J]. memo - Magazine of European Medical Oncology, 2015, 8 (1) : 52 - 56
  • [10] Diagnostic, prognostic, and therapeutic implications of genetic profiling in pleural mesothelioma
    Sadek, Ahmed
    De Rienzo, Assunta
    Bueno, Raphael
    [J]. JOURNAL OF CANCER METASTASIS AND TREATMENT, 2023, 9