Immune response profiling of malignant pleural mesothelioma for diagnostic and prognostic biomarkers

被引：6
|
作者：
Creaney, Jenette [1 ,2 ]
Dick, Ian M. [3 ]
Musk, A. W. [4 ,5 ,6 ]
Olsen, Nola J. [7 ]
Robinson, Bruce W. S. [8 ,9 ]
机构：
[1] Univ Western Australia, Sch Med & Pharmacol, Natl Ctr Asbestos Related Dis, Perth, WA, Australia
[2] Sir Charles Gairdner Hosp, Australian Mesothelioma Tissue Bank, Hosp Ave, Nedlands, WA, Australia
[3] Univ Western Australia, Sir Charles Gairdner Hosp, Sch Med & Pharmacol, Natl Ctr Asbestos Related Dis, Hosp Ave, Nedlands, WA, Australia
[4] Sir Charles Gairdner Hosp, Dept Resp Med, Hosp Ave, Nedlands, WA, Australia
[5] Univ Western Australia, Sch Populat Hlth, Natl Ctr Asbestos Related Dis, Perth, WA, Australia
[6] Univ Western Australia, Sch Med & Pharmacol, Perth, WA, Australia
[7] Univ Western Australia, Sch Populat Hlth, Perth, WA, Australia
[8] Univ Western Australia, Sch Med & Pharmacol, Natl Ctr Asbestos Related Dis, Perth, WA, Australia
[9] Sir Charles Gairdner Hosp, Dept Resp Med, Hosp Ave, Nedlands, WA, Australia
来源：
BIOMARKERS | 2016年 / 21卷 / 06期
关键词：
Biomarker; immunoreactivity; luminex; mesothelioma; protoarray; DIFFERENTIATION ANTIGEN RAB38/NY-MEL-1; SERUM MESOTHELIN; SIPULEUCEL-T; CANCER; ASBESTOS; CELL; ANTIBODIES;
D O I：
10.3109/1354750X.2016.1160429
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The asbestos induced cancer malignant mesothelioma (MM) is difficult to diagnose and has a poor prognosis. MM is an immunological cancer, therefore autoantibodies may be suitable biomarkers and associated with prognosis. We used Protoarray(R) microarrays to determine immune responses to 8798 antigens in 10MM and 10 asbestos exposed controls and developed diagnostic panels using 17 antigens from this. The AUC of these panels were independently tested in these 10MM patients and controls and in a validation group of 36 controls and 35MM patients using luminex assays; none of the antigens identified were validated. Immune responses to RAB38 were associated with a better prognosis.
引用
收藏
页码：551 / 561
页数：11
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