Net Oxidative Addition of C(sp3)-F Bonds to Iridium via Initial C-H Bond Activation

被引：145

作者：

Choi, Jongwook ^{[1
]}

Wang, David Y. ^{[1
]}

Kundu, Sabuj ^{[1
]}

Choliy, Yuriy ^{[1
]}

Emge, Thomas J. ^{[1
]}

Krogh-Jespersen, Karsten ^{[1
]}

Goldman, Alan S. ^{[1
]}

机构：

[1] Rutgers State Univ, Dept Chem & Chem Biol, New Brunswick, NJ 08903 USA

来源：

SCIENCE | 2011年 / 332卷 / 6037期

关键词：

TRANSITION-METAL-COMPLEXES; REDUCTIVE ELIMINATION; FLUORINE; REACTIVITY; CHEMISTRY; MECHANISM; HYDROGEN;

D O I：

10.1126/science.1200514

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Carbon-fluorine bonds are the strongest known single bonds to carbon and as a consequence can prove very hard to cleave. Alhough vinyl and aryl C-F bonds can undergo oxidative addition to transition metal complexes, this reaction has appeared inoperable with aliphatic substrates. We report the addition of C(sp(3))-F bonds (including alkyl-F) to an iridium center via the initial, reversible cleavage of a C-H bond. These results suggest a distinct strategy for the development of catalysts and promoters to make and break C-F bonds, which are of strong interest in the context of both pharmaceutical and environmental chemistry.

引用

页码：1545 / 1548

页数：4

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