Relationship of platelet counts, platelet volumes, and Curb-65 scores in the prognosis of COVID-19 patients

Objectives: This study investigated the relationship between 28-day mortality in patients with COVID-19 pneu-monia and the CURB-65 score, platelet count (PLT), mean platelet volume (MPV), and MPV/PLT ratio (MPR). Methods: A total of 247 patients with COVID-19 pneumonia who presented to the emergency department be-tween March 15, 2020 and May 15, 2020 were retrospectively analyzed. The age, gender, clinical presentation, history of chronic disease, thoracic computed tomography findings, MPV, PLT, MPR, CURB-65 scores, and 28 -day mortality of patients were recorded. Results: The patients had a mean age of 51 years (IQR: 39-63 years) and 55.5% were females. The most common symptom was cough (30.4% of patients). The most common comorbidity was hypertension (13.4%), 49.8% of the cases showed intermediate involvement, and 7.7% of patients died within the first 28 days. The mean MPV was 9.71 +/- 1.15, the mean PLT was 226.68 +/- 83.82, and the mean MPR was 0.056 +/- 0.12. There were significant cor-relations of 28-day mortality with the CURB-65 score, MPV, and MPR levels (p = 0.000, p = 0.034, and p = 0.034, respectively). No significant correlation was found between the PLT count and 28-day mortality (p = 0.105). Conclusions: In addition to the CURB-65 score, MPV and MPR values can be used to predict 28-day mortality in patients with COVID-19 pneumonia. (c) 2021 Elsevier Inc. All rights reserved.