Type I IFN, TLR7, MHC Class I, B Cell and OX40 Pathways Suppressed By Anifrolumab (anti-type I IFN receptor) in Moderate to Severe SLE Patients

被引：0
|
作者：
Streicher, Katie [1 ]
Wang, Jixin [1 ]
Brohawn, Philip Z. [2 ]
Higgs, Brandon W. [2 ]
Tummala, Raj [3 ]
Ranade, Koustubh [1 ]
机构：
[1] MedImmune, Translat Med, Gaithersburg, MD USA
[2] MedImmune LLC, Gaithersburg, MD USA
[3] MedImmune, Gaithersburg, MD USA
来源：
ARTHRITIS & RHEUMATOLOGY | 2018年 / 70卷
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
2684
引用
收藏
页数：2
相关论文
共 50 条
  • [1] Type I IFN Receptor and the B Cell Antigen Receptor Regulate TLR7 Responses via Distinct Molecular Mechanisms
    Poovassery, Jayakumar S.
    Bishop, Gail A.
    JOURNAL OF IMMUNOLOGY, 2012, 189 (04): : 1757 - 1764
  • [2] Regulation of cell cycle and survival by type-I IFN and TLR7 in B-lymphocytes
    Priest, Stephen
    Baumgarth, Nicole
    JOURNAL OF IMMUNOLOGY, 2009, 182
  • [3] IFN type I and type II independent enhancement of B cell TLR7 expression by natural killer cells
    Sinha, Suwan
    Guo, Yuhong
    Thet, Suwannee
    Yuan, Dorothy
    JOURNAL OF LEUKOCYTE BIOLOGY, 2012, 92 (04) : 713 - 722
  • [4] Tyrosine kinase 2 modulates splenic B cells through type I IFN and TLR7 signaling
    Bodega-Mayor, Irene
    Delgado-Wicke, Pablo
    Arrabal, Alejandro
    Alegria-Carrasco, Estibaliz
    Nicolao-Gomez, Ana
    Jaen-Castano, Marta
    Espadas, Cristina
    Dopazo, Ana
    Martin-Gayo, Enrique
    Gaspar, Maria Luisa
    de Andres, Belen
    Fernandez-Ruiz, Elena
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2024, 81 (01) : 199
  • [5] Tyrosine kinase 2 modulates splenic B cells through type I IFN and TLR7 signaling
    Jaen Castano, Marta
    Alegria Carrasco, Estibaliz
    Arrabal Sierra, Alejandro
    Delgado-Wicke, Pablo
    Bodega Mayor, Irene
    de Andres Muguruza, Belen
    Alonso-Vega, Maria Luisa Gaspar
    Fernandez Ruiz, Elena
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2024, 54 : 642 - 642
  • [6] Mycobacterium tuberculosis and TLR2 agonists inhibit induction of type I IFN by TLR7/9
    Liu, Yi
    Simmons, Daimon
    Li, Xiaoxia
    Abbott, Derek
    Boom, W.
    Harding, Clifford
    JOURNAL OF IMMUNOLOGY, 2011, 186
  • [7] TLR7 tolerance is independent of the type I IFN pathway and leads to loss of anti-tumor efficacy in mice
    Koga-Yamakawa, Erina
    Murata, Masashi
    Dovedi, Simon J.
    Wilkinson, Robert W.
    Ota, Yosuke
    Umehara, Hiroki
    Sugaru, Eiji
    Hirose, Yuko
    Harada, Hideyuki
    Jewsbury, Philip J.
    Yamamoto, Setsuko
    Robinson, David T.
    Li, Chiang J.
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 2015, 64 (10) : 1229 - 1239
  • [8] TLR7 tolerance is independent of the type I IFN pathway and leads to loss of anti-tumor efficacy in mice
    Erina Koga-Yamakawa
    Masashi Murata
    Simon J. Dovedi
    Robert W. Wilkinson
    Yosuke Ota
    Hiroki Umehara
    Eiji Sugaru
    Yuko Hirose
    Hideyuki Harada
    Philip J. Jewsbury
    Setsuko Yamamoto
    David T. Robinson
    Chiang J. Li
    Cancer Immunology, Immunotherapy, 2015, 64 : 1229 - 1239
  • [9] Severe forms of West-Nile Virus disease : the role of anti-type I IFN autoimmunity
    Lepine, Nadege
    Bahnes, Hanane
    M S-MEDECINE SCIENCES, 2025, 41 (02): : 191 - 194
  • [10] Cutting Edge: Critical Role of IκB Kinase α in TLR7/9-Induced Type I IFN Production by Conventional Dendritic Cells
    Hoshino, Katsuaki
    Sasaki, Izumi
    Sugiyama, Takahiro
    Yano, Takahiro
    Yamazaki, Chihiro
    Yasui, Teruhito
    Kikutani, Hitoshi
    Kaisho, Tsuneyasu
    JOURNAL OF IMMUNOLOGY, 2010, 184 (07): : 3341 - 3345
12345