Study of Protein Adsorption During Sterile Filtration of Protein Formulations by ILC

被引：5

作者：

Haindl, Susanne Maria Hilda ^{[1
,2
]}

Doppleb, Olivia ^{[1
,3
]}

Foerster, Lucas ^{[1
,4
]}

Wraage, Sophia ^{[1
]}

Reiche, Annette ^{[1
]}

机构：

[1] Sartorius Stedim Biotech GmbH, August Spindler Str 11, D-37089 Gottingen, Germany

[2] Leibniz Univ Hannover, Inst Tech Chem, Callinstr 5, D-30167 Hannover, Germany

[3] Tech Univ Clausthal, Inst Phys Chem, Arnold Sommerfeld Str 4, D-38678 Clausthal Zellerfeld, Germany

[4] Georg August Univ Gottingen, Inst Organ & Biomol Chem, Tammannstr 2, D-37077 Gottingen, Germany

来源：

CHEMIE INGENIEUR TECHNIK | 2020年 / 92卷 / 08期

关键词：

Inverse liquid chromatography; Protein adsorption; Sterile filtration; MEMBRANE; SURFACES; PH;

D O I：

10.1002/cite.201900185

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Protein adsorption is usually regarded as the main reason for filter fouling in sterile filtration of protein formulations. To achieve a better insight into this phenomenon, protein adsorption was studied during filtration of stabilized bovine serum albumin (BSA) and gamma-globulin formulations through 0.2-mu m microfilter membranes by inverse liquid chromatography (ILC). Adsorption processes can be studied with this method by measurement of breakthrough curves. The change of the concentration in the fluid phase is measured with high accuracy by an inline UV-detector.

引用

页码：1109 / 1121

页数：13

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