Macrophage-migration inhibitory factor: role in inflammatory diseases and graft rejection

被引：41
|
作者：
Javeed, A. [1 ]
Zhao, Y. [1 ]
Zhao, Y. [1 ]
机构：
[1] Chinese Acad Sci, China US Joint Res Ctr Life Sci, Inst Zool,Transplantat Biol Res Div, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100101, Peoples R China
来源：
INFLAMMATION RESEARCH | 2008年 / 57卷 / 02期
关键词：
macrophage migratory inhibitory factor; macrophages; transplantation; inflammation; graft rejection;
D O I：
10.1007/s00011-007-7110-6
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Macrophage migration inhibitory factor (MIF) functions as a pleiotropic protein, participating in inflammatory and immune responses. MIF was originally discovered as a lymphokine involved in delayed hypersensitivity and various macrophage functions, including production of proinflammatory cytokines, glucocorticoid-induced immunomodulator, and natural killer cell inhibitory factor (NKIF), regulation of toll-like receptor expression, adherence and phagocytosis of macrophages, as well as induction of metalloproteinase. Therefore MIF is considered as a potential target protein in many pathophysiological states. In this review, considering the protein structure and the acting mechanisms of MIF, we mainly discuss the important role of MIF in pathogenesis of inflammatory diseases and graft rejection.
引用
收藏
页码：45 / 50
页数：6
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