Synthesis and Antimicrobial Activity of Quaternary Ammonium Silane Coupling Agents

被引：11
|
作者：
Yoshino, Norio [1 ,2 ]
Sugaya, Shigenori [1 ]
Nakamura, Toshimitsu [1 ]
Yamaguchi, Yoh-hei [1 ]
Kondo, Yukishige [1 ,2 ]
Kawada, Kazuo [3 ]
Teranaka, Toshio [4 ]
机构：
[1] Tokyo Univ Sci, Fac Engn, Shinjuku Ku, Tokyo 1620826, Japan
[2] Tokyo Univ Sci, Inst Colloid & Interface Sci, Shinjuku Ku, Tokyo 1628601, Japan
[3] Kitasato Univ, Fac Sci, Minami Ku, Kanagawa 2520373, Japan
[4] Kanagawa Dent Coll, Dept Oral Med, Div Restorat Dent, Kanagawa 2388580, Japan
来源：
JOURNAL OF OLEO SCIENCE | 2011年 / 60卷 / 08期
关键词：
silane coupling agents; antimicrobial activity; surface modification; quaternary ammonium salts; minimum inhibitory concentrations; POLYMERIC PHOSPHONIUM SALTS; SURFACE MODIFICATION; FLUOROCARBON CHAIN; ANTIBACTERIAL ACTIVITY; CATIONIC BIOCIDES; COMPOSITES; GLASS;
D O I：
10.5650/jos.60.429
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Fourteen novel silane coupling agents with a quaternary ammonium group introduced into the molecule, [CH2=CHCH2N+(CH3)(CnH2n+1)(CH2)(3)Si(OCH3)(3)]X- (n-X, n=10-18, X=Cl, Br, or I), were synthesized with the aim of using these agents to make material surfaces antimicrobial for a long period of time. Measurements of the minimum inhibitory concentrations (MIC) against 12 kinds of fungi and bacteria revealed that the coupling agent with a C-10 alkyl chain and Cl- or Br- counter-ion (10-Cl or 10-Br) has the highest antimicrobial activity among the n-X agents synthesized, but 14-Cl and 14-Br showed the highest activity on a modified porcelain plate.
引用
收藏
页码：429 / 438
页数：10
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