Review on Epidermal Growth Factor Receptor (EGFR) Structure, Signaling Pathways, Interactions, and Recent Updates of EGFR Inhibitors

被引：392

作者：

Sabbah, Dima A. ^{[1
]}

Hajjo, Rima ^{[1
]}

Sweidan, Kamal ^{[2
]}

机构：

[1] Al Zaytoonah Univ Jordan, Fac Pharm, Dept Pharm, POB 130, Amman 11733, Jordan

[2] Univ Jordan, Dept Chem, Amman 11942, Jordan

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2020年 / 20卷 / 10期

关键词：

EGFR; HER-1; ERBB-1; Tyrosine kinase; EGF; TGF-alpha; mAbs; Inhibitors; cancer; TYROSINE KINASE INHIBITORS; HUMAN CANCER-CELLS; PHASE-I SAFETY; MONOCLONAL-ANTIBODY; EXTRACELLULAR DOMAIN; CRYSTAL-STRUCTURE; FACTOR-ALPHA; LUNG-CANCER; ANTITUMOR-ACTIVITY; LIGAND-BINDING;

D O I：

10.2174/1568026620666200303123102

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The epidermal growth factor receptor (EGFR) belongs to the ERBB family of tyrosine kinase receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation, division, survival, and cancer development. In this review, the EGFR structure and its mutations, signaling pathway, ligand binding and EGFR dimerization, EGF/EGFR interaction, and the progress in the development of EGFR inhibitors have been explored.

引用

页码：815 / 834

页数：20

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