Competitive inhibitor of cellular α-glucosidases protects mice from lethal dengue virus infection

被引：35
|
作者：
Chang, Jinhong [1 ]
Schul, Wouter [2 ]
Yip, Andy [2 ]
Xu, Xiaodong [3 ]
Guo, Ju-Tao [1 ]
Block, Timothy M. [1 ,3 ]
机构：
[1] Drexel Univ, Coll Med, Drexel Inst Biotechnol & Virol Res, Dept Microbiol & Immunol, Doylestwon, PA 18902 USA
[2] Novartis Inst Trop Dis, Singapore 138670, Singapore
[3] Hepatitis B Fdn, Inst Hepatitis & Virus Res, Doylestown, PA USA
来源：
ANTIVIRAL RESEARCH | 2011年 / 92卷 / 02期
关键词：
Glucosidase inhibitor; Dengue virus; Lethal infection mouse model; MOUSE MODEL; WEST-NILE; DISEASE;
D O I：
10.1016/j.antiviral.2011.08.003
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Dengue virus infection causes diseases in people, ranging from the acute febrile illness dengue fever, to life-threatening dengue hemorrhagic fever/dengue shock syndrome. We previously reported that a host cellular alpha-glucosidases I and II inhibitor, imino sugar CM-10-18, potently inhibited dengue virus replication in cultured cells, and significantly reduced viremia in dengue virus infected AG129 mice. In this report we show that CM-10-18 also significantly protects mice from death and/or disease progress in two mouse models of lethal dengue virus infection. Our results thus provide a strong support for the development of CM-10-18 or its derivatives as antiviral agents to treat servere dengue virus infections. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：369 / 371
页数：3
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