Effects of antigliomatin from the scorpion venom of Buthus martensii Karsch on chloride channels on C6 glioma cells

被引：0

作者：

Wang, Zan ^{[1
]}

Li, Mingxian ^{[2
]}

Meng, Hongmei ^{[1
]}

Huang, Min ^{[3
]}

Lin, Weihong ^{[1
]}

Cui, Li ^{[1
]}

Wang, Shao ^{[3
]}

机构：

[1] Jilin Univ, Hosp 1, Dept Neurol, Changchun 130021, Jilin Province, Peoples R China

[2] Jilin Univ, Hosp 1, Dept Resp Med, Changchun 130021, Jilin Province, Peoples R China

[3] Jilin Univ, Sch Basic Med Sci, Dept Physiol, Changchun 130021, Jilin Province, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2011年 / 6卷 / 18期

关键词：

antigliomatin; C6 glioma cells; chloride channels; osmotic pressure; whole-cell patch-clamp recording; ANTICANCER DRUG-DELIVERY; HUMAN ASTROCYTOMA-CELLS; BRAIN TUMOR-MODEL; ION CHANNELS; POTASSIUM CHANNEL; INVASION; CHLOROTOXIN; CURRENTS; MODULATION; EXPRESSION;

D O I：

10.3969/j.issn.1673-5374.2011.18.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Using whole-cell patch-clamp recordings, the effects of antigliomatin were observed on chloride channels on C6 glioma cells cultured in vitro. Antigliomatin was extracted from the venom of the scorpion Buthus martensii Karsch. Chloride channels are closed under normal osmotic pressure. When osmotic pressure was reduced to 120, 110 and 100 mV, the cell volume enlarged, chloride channels opened, and the chloride channel current increased. Three minutes after antigliomatin treatment, the chloride channel current decreased in a dose-dependent manner. These results show that antigliomatin extracted from the venom of the scorpion Buthus martensii Karsch diminishes chloride channel currents on C6 glioma cells.

引用

页码：1365 / 1369

页数：5

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