EGFR AND SRC-MEDIATED ACTIVATION OF STAT3 DRIVES RESISTANCE TO MITOTIC INHIBITORS IN GLIOBLASTOMA, AND CAN BE REVERSED WITH FDA-APPROVED DRUGS

被引：0

作者：

Kenchappa, Rajappa ^{[1
]}

Dovas, Athanassios ^{[2
]}

Argenziano, Michael ^{[2
]}

Meyer, Christian ^{[3
]}

Stopfer, Lauren ^{[4
]}

Banu, Matei ^{[2
]}

Pereira, Brianna ^{[2
]}

Griffith, Jessica ^{[5
]}

Mohammad, Afroz ^{[5
]}

Talele, Surabhi ^{[5
]}

Zarco, Natanael ^{[1
]}

Elmquist, William F. ^{[5
]}

White, Forest ^{[4
]}

Quaranta, Vito ^{[3
]}

Sims, Peter ^{[2
]}

Canoll, Peter ^{[2
]}

Rosenfeld, Steven ^{[1
]}

机构：

[1] Mayo Clin, Jacksonville, FL USA

[2] Columbia Univ, New York, NY USA

[3] Vanderbilt Univ, Nashville, TN USA

[4] MIT, Cambridge, MA USA

[5] Univ Minnesota, Minneapolis, MN USA

来源：

NEURO-ONCOLOGY | 2022年 / 24卷

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

DDDR-28

引用

页码：105 / 105

页数：1

共 8 条

[1] Activation of STAT3 through combined SRC and EGFR signaling drives resistance to a mitotic kinesin inhibitor in glioblastoma
Kenchappa, Rajappa S.
Dovas, Athanassios
Argenziano, Michael G.
Meyer, Christian T.
Stopfer, Lauren E.
Banu, Matei A.
Pereira, Brianna
Griffith, Jessica
Mohammad, Afroz
Talele, Surabhi
Haddock, Ashley
Zarco, Natanael
Elmquist, William
White, Forest
Sims, Peter
Quaranta, Vito
Sims, Peter
Canoll, Peter
Rosenfeld, Steven S.
CELL REPORTS, 2022, 39 (12):
[2] RRAD Promotes EGFR-Mediated STAT3 Activation and Induces Temozolomide Resistance of Malignant Glioblastoma
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[3] Nicotine causes alternative polarization of macrophages via Src-mediated STAT3 activation: Potential pathobiological implications
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[4] Fibronectin-mediated activation of Stat3 facilitates the resistance of triple negative breast cancer to EGFR-targeted therapies
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[5] IL-8 secreted by tumor associated macrophages contribute to lapatinib resistance in HER2-positive locally advanced breast cancer via activation of Src/STAT3/ERK1/2-mediated EGFR signaling
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[6] RESISTANCE TO ALK TYROSINE KINASE INHIBITORS IN PAEDIATRIC CANCER IS MEDIATED THROUGH ACTIVATION OF BYPASS SIGNALLING TRACKS INCLUDING IL10R/STAT3, RAS/MAP KINASE AND FGFR
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PEDIATRIC BLOOD & CANCER, 2023, 70
[7] Activation of IL-6R/JAK1/STAT3 Signaling Induces De Novo Resistance to Irreversible EGFR Inhibitors in Non-Small Cell Lung Cancer with T790M Resistance Mutation
Kim, Sun Mi
Kwon, Oh-Joon
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[8] Activation of IL-6R/JAK1/STAT3 signaling induces de novo resistance to irreversible EGFR inhibitors in non-small cell lung cancer with T790M resistance mutation
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